金催化的炔酰胺与吲哚的顺式氢芳基化反应：一类 2-乙烯基吲哚的区域和立体选择性合成。
Gold-Catalyzed cis-Hydroarylation of Ynamides with Indoles: Regio- and Stereoselective Synthesis of a Class of 2-Vinylindoles.
机构信息
Dipartimento di Scienze Farmaceutiche - Sezione di Chimica Generale e Organica "A. Marchesini", Università degli Studi di Milano Via Venezian , 21 20133 Milano, Italy.
出版信息
Org Lett. 2016 Oct 7;18(19):4798-4801. doi: 10.1021/acs.orglett.6b02189. Epub 2016 Sep 9.
PMID:27612094
Abstract
A new gold-catalyzed reaction of ynamides with 3-substituted indoles as nucleophiles is reported. The reaction allows for the synthesis of a new class of 2-vinylindole derivatives in good yields via the intermediacy of a cyclopropyl gold-carbenoid species.
摘要
本文报道了一种新的金催化反应，炔酰胺与 3-取代吲哚作为亲核试剂。该反应通过环丙基金碳烯中间体，以良好的收率合成了一类新型的 2-乙烯基吲哚衍生物。
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