Balighi K, Daneshpazhooh M, Nasimi M, Loloee S, Asadi A, Azizpour A
Dr Kamran Balighi, Associate professor of dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran; E-mail:
Mymensingh Med J. 2016 Jul;25(3):550-4.
Lichen planus (LP) is an idiopathic chronic inflammatory mucocutaneous disease. Many reports in the literature have described hepatitis B vaccine as a predisposing factor for LP. This study was performed to determine the rate of previous vaccination against hepatitis B in LP patients. This was a cross sectional study on LP patients. Diagnosis of LP was confirmed by histological examination. Data were gathered by dermatology residents based on a checklist designed to guide their interview. Blood samples were tested for HBsAB titer, HBsAg, HCV Ab and liver function tests. One hundred & twenty four (124) patients entered the study. Females were 2.72 times more affected. The mean age of patients was 45.63 years (age range; 18-88). Forty-four (35.5%) patients had been vaccinated against hepatitis B. Lichen planus during the first six months of vaccination occurred in only one patient. Our findings bring into question the causative role of HBV vaccine in LP incidence in our population.
扁平苔藓（LP）是一种特发性慢性炎症性黏膜皮肤疾病。文献中有许多报道将乙肝疫苗描述为LP的诱发因素。本研究旨在确定LP患者既往接种乙肝疫苗的比例。这是一项针对LP患者的横断面研究。LP的诊断通过组织学检查得以证实。皮肤科住院医师根据一份旨在指导访谈的清单收集数据。对血样进行乙肝表面抗体滴度、乙肝表面抗原、丙肝抗体及肝功能检查。124例患者纳入研究。女性受影响的几率是男性的2.72倍。患者的平均年龄为45.63岁（年龄范围18 - 88岁）。44例（35.5%）患者接种过乙肝疫苗。仅1例患者在接种疫苗的前6个月内发生扁平苔藓。我们的研究结果对乙肝疫苗在我国人群LP发病中的致病作用提出了质疑。
