Zhang Yunlin, Jiang Yuexia, Tang Siyuan
Institute of Endocrinology and Metabolism, Second Xiangya Hospital, Central South University, Changsha 410011,China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2014 Apr;39(4):389-94. doi: 10.3969/j.issn.1672-7347.2014.04.012.
To determine the relationship between serum omentin-1 concentration and bone mineral desity in postmenopausal women, and the adipose influence of tissue on bone mineral density (BMD).
BMD values of 336 participants were measured by dual-energy-x-ray absorptiometry (DEXA) at various skeletal sites: the anteroposterior spine, femeral neck, total hip (T-hip) and total body BMD (TBMD). Body compositions including lean tissue mass (LTM) and body fat mass (FBM) were measured by DEXA. The plasma concentrations of adipocytokines (omentin-1, adiponectin, leptin, resistin, visfatin, and apelin) were measured by ELISA.
The overweight and obese groups had higher T-hip, femerol neck, intertrochanter BMD than the nomal weight group. Plasma omentin-1 was negatively correlated with anteroposterior spine, femeral neck, trochanter, intertrochanter, T-hip and Ward's BMD, after adjustment for age, BMI and fat body mass, and the correlation was not significant. Multiple stepwise regression anlysis revealed that lean body mass, menopause duration and estrogen level were the most important variables affecting the BMD and each explained 12.2%-13.7%, 6.9%-13.1%, 0.9%-1.7% of the variance. Serum adiponectin was independently associated with T-hip, lumbar spine and total BMD.
Plasma omentin-1 is not significantly correlated with BMD in postmenopausal women. Lean body mass, menopause duration and estrogen level are the most important variables affecting the BMD. Serum adiponectin is an independent predictor of T-hip, lumbar spine and total BMD.
确定绝经后女性血清网膜素-1浓度与骨密度之间的关系，以及组织脂肪对骨密度（BMD）的影响。
采用双能X线吸收法（DEXA）测量336名参与者在不同骨骼部位的骨密度值：腰椎前后位、股骨颈、全髋（T-髋）和全身骨密度（TBMD）。通过DEXA测量包括瘦体重（LTM）和体脂量（FBM）在内的身体成分。采用酶联免疫吸附测定法（ELISA）测量脂肪细胞因子（网膜素-1、脂联素、瘦素、抵抗素、内脂素和Apelin）的血浆浓度。
超重和肥胖组的T-髋、股骨颈、大转子间骨密度高于正常体重组。在调整年龄、BMI和脂肪量后，血浆网膜素-1与腰椎前后位、股骨颈、大转子、大转子间、T-髋和Ward三角区骨密度呈负相关，但相关性不显著。多元逐步回归分析显示，瘦体重、绝经持续时间和雌激素水平是影响骨密度的最重要变量，各解释了12.2%-13.7%、6.9%-13.1%、0.9%-1.7%的变异。血清脂联素与T-髋、腰椎和全身骨密度独立相关。
绝经后女性血浆网膜素-1与骨密度无显著相关性。瘦体重、绝经持续时间和雌激素水平是影响骨密度的最重要变量。血清脂联素是T-髋、腰椎和全身骨密度的独立预测因子。
