Salehi Somayeh, Jafarian Amir Hossein, Montazer Mehdi, Moghbeli Meysam, Forghanifard Mohammad Mahdi
Cancer Molecular Research Center, Ghaem Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Dr Moaven Hospital, Kermanshah University of Medical Sciences, Sahneh, Kermanshah, Iran.
J Gastrointest Cancer. 2017 Jun;48(2):151-155. doi: 10.1007/s12029-016-9874-9.
Evading apoptosis is one of the major hallmarks of cancer cells. Inhibitors of apoptosis (IAPs) proteins are considered as a most important gene families involved in apoptosis. BRUCE protein, a member of IAPs, is able to quench apoptosis as well as playing role in cell division. Our aim in this study was to analyze BRUCE protein expression in gastric carcinoma (GC) and its correlation with the clinicopathological features.
Using immunohistochemistry, 52 GC specimens were studied for BRUCE protein expression. A validated scoring method was applied.
BRUCE protein expression was detected in majority of tumor tissues (98.07 %). A significant correlation between gender and BRUCE expression (p = 0.024) was detected. Indeed, females showed higher level of BRUCE expression than male patients.
Since specific expression of BRUCE protein was revealed in majority of GC tissues, BRUCE protein may be a useful therapeutic target for cancer therapy. Furthermore, based on the native role of BRUCE protein in inhibition of apoptosis, using this protein in targeted therapy of tumor cells may help to inhibit tumor cells growth and survival leading to rapid elimination of tumor mass.
逃避细胞凋亡是癌细胞的主要特征之一。凋亡抑制蛋白（IAPs）家族被认为是参与细胞凋亡的最重要基因家族之一。BRUCE蛋白作为IAPs家族成员，既能抑制细胞凋亡，又在细胞分裂中发挥作用。本研究旨在分析BRUCE蛋白在胃癌（GC）中的表达及其与临床病理特征的相关性。
采用免疫组织化学方法，对52例GC标本进行BRUCE蛋白表达研究，并应用经过验证的评分方法。
大多数肿瘤组织（98.07%）检测到BRUCE蛋白表达。检测到性别与BRUCE表达之间存在显著相关性（p = 0.024）。事实上，女性患者的BRUCE表达水平高于男性患者。
由于大多数GC组织中均显示出BRUCE蛋白的特异性表达，BRUCE蛋白可能是癌症治疗的一个有用的治疗靶点。此外，基于BRUCE蛋白在抑制细胞凋亡中的固有作用，在肿瘤细胞的靶向治疗中使用该蛋白可能有助于抑制肿瘤细胞的生长和存活，从而快速消除肿瘤块。
