空气中颗粒物和雨水中的致癌性色氨酸热解产物。

Carcinogenic tryptophan pyrolysis products in airborne particles and rain water.

作者信息

Manabe S, Uchino E, Wada O

机构信息

Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo, Japan.

出版信息

Mutat Res. 1989 Aug;226(4):215-21. doi: 10.1016/0165-7992(89)90072-9.

DOI:10.1016/0165-7992(89)90072-9

PMID:2761562

Abstract

This is the first report that carcinogenic tryptophan pyrolysis products are present in airborne particles and rain water. The airborne particles were collected from August 1988 through October 1988 at 4 locations in Japan. The amounts of 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in the air were 0.23 +/- 0.17 pg/m3 air (mean +/- SD, n = 18) and 0.16 +/- 0.15 pg/m3 air (n = 18), respectively. Moreover, these carcinogens were detected in rain water. These results indicate that Trp-P-1 and Trp-P-2 are ubiquitous environmental components.

摘要

这是关于致癌性色氨酸热解产物存在于空气颗粒物和雨水中的首次报告。空气颗粒物于1988年8月至1988年10月在日本的4个地点采集。空气中3-氨基-1,4-二甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-1）和3-氨基-1-甲基-5H-吡啶并[4,3-b]吲哚（Trp-P-2）的含量分别为0.23±0.17 pg/m³空气（平均值±标准差，n = 18）和0.16±0.15 pg/m³空气（n = 18）。此外，这些致癌物在雨水中也被检测到。这些结果表明，Trp-P-1和Trp-P-2是普遍存在的环境成分。