Department of Psychiatry, Yonsei University College of Medicine, Seoul, Republic of Korea.
Institute of Behavioral Science in Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Sci Rep. 2016 Sep 12;6:32564. doi: 10.1038/srep32564.
Evidence from literature supports the existence of associations between serotonin-related genetic variants and obsessive-compulsive disorder (OCD), but few studies have explored the involvement of serotonin receptor type 3 genes (HTR3) in OCD. To identify whether HTR3 variability affects an individual's susceptibility to OCD, we examined 10 HTR3 variants in 596 individuals with OCD and 599 controls. A significant difference existed in the genotypic distribution of the HTR3B variant rs1176744 between individuals with OCD and controls (odds ratio [OR] = 0.74, 95% confidence interval [CI] = 0.60-0.91, P = 0.0043). A protective haplotype in HTR3B was also associated with OCD (OR = 0.77, CI = 0.63-0.95, permutated P = 0.0179). Analyses of OCD sub-phenotypes demonstrated significant associations between rs3758987 and early onset OCD in male subjects (OR = 0.49, CI = 0.31-0.79, P = 0.0031) and among rs6766410, rs6443930, and the cleaning dimension in female subjects (OR = 0.36, CI = 0.18-0.69, P = 0.0016 and OR = 0.47, CI = 0.29-0.79, P = 0.0030, respectively). Additionally, rs6766410 was related to contamination-based disgust in OCD (P = 0.0044). These results support that common HTR3 variants are involved in OCD and some of its clinical phenotypes.
来自文献的证据支持血清素相关基因变异与强迫症（OCD）之间存在关联，但很少有研究探讨血清素受体 3 型基因（HTR3）在 OCD 中的作用。为了确定 HTR3 变异是否会影响个体对 OCD 的易感性，我们在 596 名 OCD 患者和 599 名对照者中检查了 10 种 HTR3 变异。在 OCD 患者和对照组之间，HTR3B 变异 rs1176744 的基因型分布存在显著差异（比值比 [OR] = 0.74，95%置信区间 [CI] = 0.60-0.91，P = 0.0043）。HTR3B 中的保护性单倍型也与 OCD 相关（OR = 0.77，CI = 0.63-0.95，置换 P = 0.0179）。对 OCD 亚表型的分析表明，rs3758987 与男性患者的早发性 OCD 之间存在显著关联（OR = 0.49，CI = 0.31-0.79，P = 0.0031），而 rs6766410、rs6443930 和清洁维度之间在女性患者中也存在显著关联（OR = 0.36，CI = 0.18-0.69，P = 0.0016 和 OR = 0.47，CI = 0.29-0.79，P = 0.0030）。此外，rs6766410 与 OCD 中的污染相关厌恶有关（P = 0.0044）。这些结果支持常见的 HTR3 变异与 OCD 及其某些临床表型有关。
