自身免疫性甲状腺疾病患者血清 BAFF 与甲状腺自身抗体的研究
Serum BAFF and thyroid autoantibodies in autoimmune thyroid disease.
机构信息
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; Division of Endocrinology, Department of Internal Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC; Division of Endocrinology and Metabolism, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC; Department of Medical Research, Shuang-Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC.
出版信息
Clin Chim Acta. 2016 Nov 1;462:96-102. doi: 10.1016/j.cca.2016.09.004. Epub 2016 Sep 8.
BACKGROUND
This study investigated the association of serum B-lymphocyte activating factor (BAFF) levels with autoimmune thyroid disease (AITD) in a Chinese population.
MATERIALS AND METHODS
We enrolled 221 patients with AITD [170 patients with Graves' disease (GD), 51 patients with Hashimoto's thyroiditis (HT)], and 124 healthy controls. Serum BAFF levels, thyroid function and thyroid autoantibody (TAb) levels, including of thyroid-stimulating hormone receptor antibody (TSHRAb), anti-thyroid peroxidase antibody (Anti-TPO Ab), and antithyroglobulin antibody (ATA), were measured at baseline.
RESULTS
Serum BAFF levels were higher in the GD, HT, and AITD groups than in the control group. Significant correlations were observed between BAFF and TSHRAb levels (r=0.238, p=0.018), between BAFF and Anti-TPO Ab levels (p=0.038), and between BAFF and ATA titers (p=0.025) in women but not in men. In addition, serum BAFF levels were significantly associated with free thyroxine (r=0.430, p=0.004) and TSHRAb (r=0.495, p=0.001) levels in women with active GD but not in those with inactive GD.
CONCLUSIONS
Serum BAFF levels are increased in GD, HT, and AITD. The correlation between serum BAFF and TAb levels exhibits a dimorphic pattern, particularly in active GD.
背景
本研究旨在探讨中国人群血清 B 淋巴细胞激活因子（BAFF）水平与自身免疫性甲状腺疾病（AITD）的相关性。
材料与方法
共纳入 221 例 AITD 患者[170 例格雷夫斯病（GD）患者，51 例桥本甲状腺炎（HT）患者]和 124 例健康对照者。在基线时测量了血清 BAFF 水平、甲状腺功能和甲状腺自身抗体（TAb）水平，包括促甲状腺激素受体抗体（TSHRAb）、抗甲状腺过氧化物酶抗体（Anti-TPO Ab）和抗甲状腺球蛋白抗体（ATA）。
结果
GD、HT 和 AITD 组的血清 BAFF 水平均高于对照组。在女性中，BAFF 与 TSHRAb 水平之间（r=0.238，p=0.018）、BAFF 与 Anti-TPO Ab 水平之间（p=0.038）以及 BAFF 与 ATA 滴度之间（p=0.025）存在显著相关性，但在男性中无相关性。此外，在活动期 GD 女性中，血清 BAFF 水平与游离甲状腺素（r=0.430，p=0.004）和 TSHRAb（r=0.495，p=0.001）水平呈显著相关，但在非活动期 GD 女性中无相关性。
结论
GD、HT 和 AITD 患者的血清 BAFF 水平升高。血清 BAFF 与 TAb 水平之间的相关性呈双相模式，尤其是在活动期 GD 中更为明显。
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