福氏耐格里阿米巴的生物学与发病机制。
Biology and pathogenesis of Naegleria fowleri.
作者信息
Siddiqui Ruqaiyyah, Ali Ibne Karim M, Cope Jennifer R, Khan Naveed Ahmed
机构信息
Department of Biological Sciences, Faculty of Science and Technology, Sunway University, Bandar Sunway, Selangor, Malaysia.
Waterborne Disease Prevention Branch, Division of Foodborne Waterborne and Environmental Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
出版信息
Acta Trop. 2016 Dec;164:375-394. doi: 10.1016/j.actatropica.2016.09.009. Epub 2016 Sep 9.
Naegleria fowleri is a protist pathogen that can cause lethal brain infection. Despite decades of research, the mortality rate related with primary amoebic meningoencephalitis owing to N. fowleri remains more than 90%. The amoebae pass through the nose to enter the central nervous system killing the host within days, making it one of the deadliest opportunistic parasites. Accordingly, we present an up to date review of the biology and pathogenesis of N. fowleri and discuss needs for future research against this fatal infection.
福氏耐格里阿米巴是一种可导致致命脑部感染的原生生物病原体。尽管经过了数十年的研究，但由福氏耐格里阿米巴引起的原发性阿米巴脑膜脑炎的死亡率仍超过90%。这种阿米巴通过鼻腔进入中枢神经系统，在数天内杀死宿主，使其成为最致命的机会性寄生虫之一。因此，我们对福氏耐格里阿米巴的生物学和发病机制进行了最新综述，并讨论了针对这种致命感染的未来研究需求。
Zotero 插件