Baune Bernhard T, Air Tracy
Discipline of Psychiatry, School of Medicine, University of Adelaide , Adelaide, SA , Australia.
Front Psychiatry. 2016 Aug 26;7:150. doi: 10.3389/fpsyt.2016.00150. eCollection 2016.
Cross-sectional and longitudinal studies exploring clinical, functional, and biological correlates of major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, we chose to focus the phenotypic assessments on three cognitive dimensions of depression including (a) cognitive performance, (b) emotion processing, and (c) social cognitive functioning. Hence, the overall aim of the study is to investigate the long-term clinical course of these cognitive dimensions in depression and its functional (psychosocial) correlates. We also aim to identify biological "genomic" correlates of these three cognitive dimensions of depression. To address the above overall aim, we created the Cognition and Mood Study (CoFaMS) with the key objective to investigate the clinical, functional, and biological correlates of cognitive dimensions of depression by employing a prospective study design and including a healthy control group. The study commenced in April 2015, including patients with a primary diagnosis of a major depressive episode of major depressive disorder or bipolar disorder according to DSM-IV-TR criteria. The assessments cover the three cognitive dimensions of depression (cognitive performance, emotion processing, and social cognition), cognitive function screening instrument, plus functional scales to assess general, work place, and psychosocial function, depression symptom scales, and clinical course of illness. Blood is collected for comprehensive genomic discovery analyses of biological correlates of cognitive dimensions of depression. The CoFaM-Study represents an innovative approach focusing on cognitive dimensions of depression and its functional and biological "genomic" correlates. The CoFaMS team welcomes collaborations with both national and international researchers.
探索重度抑郁症临床、功能和生物学关联的横断面研究和纵向研究屡见不鲜。在这类研究中，抑郁症最常被定义为基于使用诊断工具的研究得出的分类诊断。鉴于抑郁症在表型和生物学上的异质性，我们选择将表型评估聚焦于抑郁症的三个认知维度，包括：（a）认知表现，（b）情绪加工，以及（c）社会认知功能。因此，本研究的总体目标是调查抑郁症中这些认知维度的长期临床病程及其功能（心理社会）关联。我们还旨在确定抑郁症这三个认知维度的生物学“基因组”关联。为实现上述总体目标，我们创建了认知与情绪研究（CoFaMS），其主要目标是通过采用前瞻性研究设计并纳入健康对照组，来调查抑郁症认知维度的临床、功能和生物学关联。该研究于2015年4月开始，纳入了根据《精神疾病诊断与统计手册》第四版修订版（DSM-IV-TR）标准被初步诊断为重度抑郁症发作或双相情感障碍的患者。评估涵盖抑郁症的三个认知维度（认知表现、情绪加工和社会认知）、认知功能筛查工具以及用于评估总体、工作场所和心理社会功能的功能量表、抑郁症状量表和疾病临床病程。采集血液用于对抑郁症认知维度的生物学关联进行全面的基因组发现分析。CoFaM研究代表了一种聚焦于抑郁症认知维度及其功能和生物学“基因组”关联的创新方法。CoFaMS团队欢迎与国内和国际研究人员开展合作。
