Zhu Tian Hao, Rodriguez Paola G, Behan James W, Declerck Brittney, Kim Gene H
Departments of Dermatology University of Southern California Keck School of Medicine, Los Angeles, California.
Dermatol Online J. 2016 Jun 15;22(6):13030/qt2hs2s4nb.
Cryptococcus neoformans is a common fungus found throughout the environment that causes opportunistic disease in immunocompromised individuals. Infection of humans with C neoformans usually manifests as lung disease through inhalation of spores or meningoencephalitis by involvement of the central nervous system. Rarely, dissemination in the form of cutaneous lesions can occur in individuals with long term immunosuppression. We present a patient with C. neoformans manifesting as cellulitis with focal segmental glomerulosclerosis treated with corticosteroids. Because of the mortality associated with disseminated cryptococcosis, early identification, especially of atypical cutaneous presentations is critical from a dermatological perspective.
新型隐球菌是一种常见于整个环境中的真菌，可在免疫功能低下的个体中引起机会性疾病。人类感染新型隐球菌通常通过吸入孢子表现为肺部疾病，或因中枢神经系统受累而表现为脑膜脑炎。很少情况下，长期免疫抑制的个体可能会出现皮肤病变形式的播散。我们报告一例新型隐球菌表现为蜂窝织炎并伴有局灶节段性肾小球硬化的患者，该患者接受了皮质类固醇治疗。由于播散性隐球菌病相关的死亡率，从皮肤病学角度来看，早期识别，尤其是非典型皮肤表现的识别至关重要。
