通过铑催化 2-芳基吡啶和 3-重氮吲哚啉-2-亚胺之间的偶联反应制备 3-芳基-2-氨基吲哚。
Preparation of 3-Aryl-2-aminoindoles via Rhodium-Catalyzed Coupling Reaction between 2-Arylpyridines and 3-Diazoindolin-2-imines.
机构信息
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
出版信息
J Org Chem. 2016 Oct 7;81(19):9433-9437. doi: 10.1021/acs.joc.6b01678. Epub 2016 Sep 21.
PMID:27617675
Abstract
Rhodium-catalyzed coupling reaction of 3-diazoindolin-2-imines with 2-arylpyridines, 2-phenylpyrimidines, or 1-phenylpyrazoles furnished the corresponding 3-aryl-2-aminoindoles in moderate to excellent yields. A variety of functional groups were tolerant to the reaction conditions.
摘要
铑催化的 3-重氮吲哚-2-亚胺与 2-芳基吡啶、2-苯基嘧啶或 1-苯基吡唑的偶联反应以中等至优异的收率得到相应的 3-芳基-2-氨基吲哚。多种官能团对反应条件具有耐受性。
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