Rh 催化的 3-重氮吲哚啉-2-亚胺反应：吡啶并吲哚和四氢呋喃并吡咯并吲哚的合成。
Rh-Catalyzed Reactions of 3-Diazoindolin-2-imines: Synthesis of Pyridoindoles and Tetrahydrofuropyrroloindoles.
机构信息
Department of Chemistry, Zhejiang University , Hangzhou 310027, P. R. China.
出版信息
Org Lett. 2015 Sep 18;17(18):4412-5. doi: 10.1021/acs.orglett.5b01943. Epub 2015 Sep 8.
PMID:26349028
Abstract
The rhodium-catalyzed reactions of 3-diazoindolin-2-imines with furans and dihydrofuran furnished 9H-pyrido[2,3-b]indoles and tetrahydrofuro[3',2':4,5]pyrrolo[2,3-b]indoles, respectively. A cascade reaction mechanism involving an α-imino rhodium carbene intermediate is proposed. The starting materials are readily available, and the procedure is facile and efficient.
摘要
铑催化的 3-重氮吲哚啉-2-亚胺与呋喃和二氢呋喃的反应分别生成了 9H-吡啶并[2,3-b]吲哚和四氢呋喃并[3',2':4,5]吡咯并[2,3-b]吲哚。提出了一个涉及α-亚氨基铑卡宾中间体的级联反应机制。起始原料易得，操作简便高效。
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