Hussein Ahmed A, Yango Pamela, Ezz Youseff, Smith James F, Tran Nam D
Department of Urology, Cairo University, Il Cairo, Egypt -
Minerva Ginecol. 2016 Dec;68(6):668-74.
Infertility is a common disease affecting 10-15% of reproductive couples with significant psychological and financial impacts to both patients and society. Approximately 80 million people worldwide are infertile, with an increasing incidence of male infertility. Semen cryopreservation in adults is a proven method of fertility preservation for male patients undergoing gonadal toxic therapies. Unlike adults who can cryopreserve sperm at any time prior to gonadal toxic treatments, there are no effective fertility preservation options for children undergoing cancer treatment, a time when semen cryopreservation is not feasible. Thus, most of the childhood cancer survivor will develop irreversible azoospermia due to the gonadal toxicity of the treatment on spermatogononial stem cells. This review will summarize the possible options and challenges of fertility preservation in this vulnerable population.
不孕症是一种常见疾病，影响着10%至15%的育龄夫妇，给患者和社会带来了重大的心理和经济影响。全球约有8000万人患有不孕症，男性不育症的发病率呈上升趋势。对于接受性腺毒性治疗的成年男性患者，精液冷冻保存是一种经证实的生育力保存方法。与成年人在接受性腺毒性治疗前可随时冷冻精子不同，对于正在接受癌症治疗的儿童，目前尚无有效的生育力保存方法，因为此时精液冷冻保存不可行。因此，大多数儿童癌症幸存者会因治疗对精原干细胞的性腺毒性而发展为不可逆的无精子症。本综述将总结这一弱势群体生育力保存的可能选择和挑战。
