光谱学、结构特征及抗氧化能力的烟酸铬（III）化合物作为糖尿病药物模型。
Spectroscopic, structural characterizations and antioxidant capacity of the chromium (III) niacinamide compound as a diabetes mellitus drug model.
机构信息
Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia; Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt.
Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi Arabia; Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, Egypt.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2017 Feb 15;173:122-131. doi: 10.1016/j.saa.2016.08.053. Epub 2016 Aug 30.
New binuclear chromium (III) niacinamide compound with chemical formula [Cr(Nic)(Cl)(HO)]·HO was obtained upon the reaction of chromium (III) chloride with niacinamide (Nic) in methanol solvent at 60°C. The proposed structure was discussed with the help of microanalytical analyses, conductivity, spectroscopic (FT-IR and UV-vis.), magnetic calculations, thermogravimetric analyses (TG/TGA), and morphological studies (X-ray of solid powder and scan electron microscopy. The infrared spectrum of free niacinamide in comparison with its chromium (III) compound indicated that the chelation mode occurs via both nitrogen atoms of pyridine ring and primary -NH group. The efficiency of chromium (III) niacinamide compound in decreasing of glucose level of blood and HbA1c in case of diabetic rats was checked. The ameliorating gluconeogenic enzymes, lipid profile and antioxidant defense capacities are considered as an indicator of the efficiency of new chromium (III) compound as antidiabetic drug model.
在 60°C 的甲醇溶剂中，三价铬氯化物与烟酰胺（Nic）反应，得到了化学式为[Cr（Nic）（Cl）（HO）]·HO 的新型双核铬（III）烟酰胺化合物。通过微量分析、电导率、光谱（FT-IR 和 UV-vis.）、磁计算、热重分析（TG/TGA）和形态研究（固态粉末 X 射线和扫描电子显微镜）对所提出的结构进行了讨论。与游离烟酰胺的红外光谱相比，其铬（III）化合物表明螯合模式通过吡啶环的两个氮原子和仲-NH 基团发生。检查了铬（III）烟酰胺化合物在降低糖尿病大鼠血糖和 HbA1c 水平方面的效率。改善糖异生酶、脂质谱和抗氧化防御能力被认为是新型铬（III）化合物作为抗糖尿病药物模型的效率的指标。
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