Bexton Steve, Nelson Helen
Royal Society for the Prevention of Cruelty to Animals (RSPCA) East Winch Wildlife Centre, Station Road, East Winch, Kings Lynn, Norfolk, PE32 1NR, UK.
Vet Dermatol. 2016 Dec;27(6):500-e133. doi: 10.1111/vde.12378. Epub 2016 Sep 12.
Dermatophytosis caused by Trichophyton erinacei is a common scaling and crusting skin disease affecting European hedgehogs (Erinaceus europaeus) admitted to wildlife rescue centres. The application of topical therapy can be challenging because wild hedgehogs are subject to stress and often roll into a ball when handled. Systemic antifungal therapy is more convenient but has not been evaluated in this species.
HYPOTHESIS/OBJECTIVES: To compare the efficacy of oral itraconazole versus oral terbinafine for the treatment of dermatophytosis affecting hedgehogs.
A treatment trial was undertaken in a wildlife hospital involving 165 hedgehogs with naturally occurring dermatophytosis.
Animals were randomly divided into two groups and treated with either itraconazole or terbinafine orally for 28 days. The therapeutic efficacy was evaluated after 14 and 28 days by mycological culture and clinical dermatological lesion scores.
Both drugs were well tolerated and clinically effective. After 14 and 28 days of treatment, the respective mycological cure rate was 36.6% and 65.9% for the itraconazole-treated group and 92.8% and 98.8% for the terbinafine-treated group.
Itraconazole and terbinafine were both effective for the treatment of dermatophytosis affecting hedgehogs; however, terbinafine was more effective.
由刺毛癣菌引起的皮肤癣菌病是一种常见的脱屑和结痂性皮肤病，影响入住野生动物救助中心的欧洲刺猬（ Erinaceus europaeus ）。局部治疗的应用可能具有挑战性，因为野生刺猬容易受到应激，处理时常常会蜷缩成一团。全身抗真菌治疗更方便，但尚未在该物种中进行评估。
假设/目的：比较口服伊曲康唑与口服特比萘芬治疗刺猬皮肤癣菌病的疗效。
在一家野生动物医院对165只患有自然发生的皮肤癣菌病的刺猬进行了一项治疗试验。
将动物随机分为两组，分别口服伊曲康唑或特比萘芬，治疗28天。在治疗14天和28天后，通过真菌培养和临床皮肤病损评分评估治疗效果。
两种药物耐受性良好且临床有效。治疗14天和28天后，伊曲康唑治疗组的真菌治愈率分别为36.6%和65.9%，特比萘芬治疗组分别为92.8%和98.8%。
伊曲康唑和特比萘芬对治疗刺猬的皮肤癣菌病均有效；然而，特比萘芬更有效。
