Yoshikawa Y, Truong L D, Fraire A E, Kim H S
Department of Pathology, Baylor College of Medicine, Houston, Texas.
Mod Pathol. 1989 May;2(3):233-8.
This study underscores an unexpectedly high incidence of histologic abnormalities in 33 testes from 31 patients who died of acquired immunodeficiency syndrome. Histologic changes of seminiferous tubules were classified into five categories: "Sertoli cell only" (14 testes, 42%), hypospermatogenesis (9, 27%), peritubular fibrosis and tubular hyalinization (5, 15%), maturation arrest (4, 12%), and normal (1, 3%). Significant interstitial fibrosis was found in 18 testes and mild lymphocytic infiltration in 5. Leydig cells were increased in 4 and decreased in 12. Opportunistic infections or Kaposi's sarcoma were not found in any of these testes. Possible explanations for the high incidence of the testicular abnormalities include direct viral cytopathic effect, antisperm antibody produced by homosexual activities, and thermal damage to the germ cells due to prolonged febrile state.
本研究强调，在31例死于获得性免疫缺陷综合征患者的33个睾丸中，组织学异常的发生率出乎意料地高。生精小管的组织学变化分为五类：“仅支持细胞”（14个睾丸，42%）、精子发生低下（9个，27%）、管周纤维化和小管透明变性（5个，15%）、成熟停滞（4个，12%）以及正常（1个，3%）。18个睾丸发现有明显的间质纤维化，5个有轻度淋巴细胞浸润。4个睾丸的间质细胞增多，12个减少。这些睾丸均未发现机会性感染或卡波西肉瘤。睾丸异常发生率高的可能解释包括直接病毒细胞病变效应、同性恋活动产生的抗精子抗体以及长期发热状态对生殖细胞的热损伤。
