Poljak-Blazi M, Osmak M, Hadzija M
Photochem Photobiol. 1989 Jul;50(1):85-9. doi: 10.1111/j.1751-1097.1989.tb04132.x.
Sensitivity of mouse bone marrow and myeloid leukemia cells as well as the sensitivity of human myeloid leukemia cells to UV light was tested. Criteria were the in vivo colony-forming ability of UV exposed cells and the inhibition of DNA synthesis during post-irradiation incubation for 24 h in vitro. Mouse bone marrow cells irradiated with a small dose of UV light (5 J/m2) and injected into x-irradiated animals did not form hemopoietic colonies on the recipients' spleens, and the recipients died. However, mouse leukemia cells, after irradiation with higher doses of UV light, retained the ability to form colonies on the spleens, and all recipient mice died with typical symptoms of leukemia. In vitro, mouse bone marrow cells exhibited high sensitivity to UV light as compared to mouse myeloid leukemia cells. Human leukemia cells were also resistant to UV light, but more sensitive than mouse leukemia cells. These results indicate that myeloid leukemia cells are resistant to UV light as compared with normal bone marrow cells.
测试了小鼠骨髓细胞、髓系白血病细胞以及人类髓系白血病细胞对紫外线的敏感性。评判标准为紫外线照射后细胞在体内形成集落的能力以及体外照射后24小时孵育期间DNA合成的抑制情况。用小剂量紫外线（5 J/m²）照射的小鼠骨髓细胞注入经X射线照射的动物体内后，在受体脾脏上未形成造血集落，受体死亡。然而，用较高剂量紫外线照射后的小鼠白血病细胞仍保留在脾脏上形成集落的能力，所有受体小鼠均死于典型的白血病症状。在体外，与小鼠髓系白血病细胞相比，小鼠骨髓细胞对紫外线表现出高敏感性。人类白血病细胞对紫外线也有抗性，但比小鼠白血病细胞更敏感。这些结果表明，与正常骨髓细胞相比，髓系白血病细胞对紫外线具有抗性。
