Ohmae Masashi, Kojima Mei, Mihara Kenta, Yamazaki Yuji, Hara Isao, Hara Eri, Kimura Shunsaku
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto daigaku-katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto daigaku-katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Bioorg Med Chem Lett. 2016 Oct 15;26(20):4976-4982. doi: 10.1016/j.bmcl.2016.09.004. Epub 2016 Sep 4.
Effects of sialic acid coatings on polymeric micelle consisting of poly(sarcosine)-block-poly(l-lactic acid) (Lactosome) in the aim of prevention of the accelerated blood clearance (ABC) phenomenon are studied. Two kinds of the sialic acid-presenting Lactosomes targeting the immunosuppressive receptors of Siglec-G and CD22 have been successfully prepared. Lactosome presenting 5-N-acetylneuraminic acid or 5-N-acetylneuraminyl-α(2→6)-galactosyl-β(1→4)-N-acetylglucosamine at the nanocarrier surface diminished the ABC phenomenon due to the reduction of the anti-poly(sarcosine) IgM production. Further, the sialic acid moieties could interact possibly with Siglec-E on immune cell to suppress phagocytosis of the opsonized nanocarriers.
研究了唾液酸包被对由聚（肌氨酸）-嵌段-聚（L-乳酸）组成的聚合物胶束（乳粒）的影响，目的是防止加速血液清除（ABC）现象。已成功制备了两种靶向Siglec-G和CD22免疫抑制受体的唾液酸修饰乳粒。在纳米载体表面呈现5-N-乙酰神经氨酸或5-N-乙酰神经氨酰-α(2→6)-半乳糖基-β(1→4)-N-乙酰葡糖胺的乳粒由于抗聚（肌氨酸）IgM产生的减少而减轻了ABC现象。此外，唾液酸部分可能与免疫细胞上的Siglec-E相互作用，以抑制调理纳米载体的吞噬作用。
