Pijpers Eva L, Kreijkamp-Kaspers Sanne, McGuire Treasure M, Deckx Laura, Brodribb Wendy, van Driel Mieke L
Faculty of Medicine, Rijksuniversiteit Groningen, Groningen, The Netherlands.
Discipline of General Practice, School of Medicine, The University of Queensland, Brisbane, Queensland, Australia.
Aust N Z J Obstet Gynaecol. 2017 Jun;57(3):334-341. doi: 10.1111/ajo.12531. Epub 2016 Sep 14.
For many medicines, safe use during pregnancy is not established and adherence is often poor due to safety concerns. Therefore, it is important to identify consumers' medicines information needs during pregnancy.
A retrospective, mixed methods analysis was conducted on eight years of pregnancy-related calls to an Australian national medicines call centre. The call profile of pregnancy and non-pregnancy-related questions were compared. Medicines involved in pregnancy calls were categorised by class (Anatomical Therapeutic Chemical (ATC)3 level), and Therapeutic Goods Administration pregnancy category. Questions in these calls were also themed by pregnancy stage.
We identified 4573 pregnancy-related and 118 547 non-pregnancy-related calls. The caller profile for pregnancy-related calls was female (93.7%), asking for herself (83.0%), and while 70.1% of questions involved one medicine, 9.6% involved three or more medicines. Pregnancy enquiries were prompted more often by conflicting information, inadequate information or desire for a second opinion. For 1166 calls, where the stage of pregnancy was available, most questions concerned safety. Medication classified as 'safe' during pregnancy accounted for 34% of these questions. After antidepressants, most calls were made about over-the-counter (OTC) medicines (paracetamol, dexchlorpheniramine, codeine). Safe treatment for everyday conditions was of increasing concern as the pregnancy progressed.
Pregnant women are concerned about the safety of medication use in pregnancy and a significant proportion overestimate risk. Psychotropic medication and fertility are strong drivers to seek information during preconception. Everyday illnesses and self-medication with OTC medication are a common concern throughout pregnancy, even though many medicines are safe to use.
对于许多药物而言，孕期安全使用的情况尚未明确，且由于安全担忧，药物依从性往往较差。因此，确定消费者在孕期的用药信息需求非常重要。
对澳大利亚国家药物咨询中心八年来接到的与怀孕相关的咨询电话进行了回顾性混合方法分析。比较了与怀孕相关问题和非怀孕相关问题的咨询概况。将与怀孕咨询电话中涉及的药物按类别（解剖治疗化学（ATC）3级）和治疗用品管理局的孕期分类进行归类。这些咨询电话中的问题也按孕期阶段进行了主题分类。
我们识别出4573个与怀孕相关的咨询电话和118547个非怀孕相关的咨询电话。与怀孕相关咨询电话的来电者概况为女性（93.7%），咨询自身情况（83.0%），虽然70.1%的问题涉及一种药物，但9.6%的问题涉及三种或更多药物。怀孕相关咨询更多是由相互矛盾的信息、信息不足或希望获得第二种意见引发的。在1166个可得知孕期阶段的咨询电话中，大多数问题涉及安全性。孕期被归类为“安全”的药物占这些问题的34%。在抗抑郁药之后，大多数咨询电话是关于非处方药（对乙酰氨基酚、右氯苯那敏、可待因）的。随着孕期进展，日常疾病的安全治疗愈发受到关注。
孕妇担心孕期用药的安全性，且很大一部分人高估了风险。精神药物和生育能力是孕前寻求信息的强烈驱动因素。日常疾病和使用非处方药进行自我药疗在整个孕期都是常见的担忧，尽管许多药物使用起来是安全的。
