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美敦力植入式心脏复律除颤器中的传感与检测

Sensing and detection in Medtronic implantable cardioverter defibrillators.

作者信息

Brown Mark L, Swerdlow Charles D

机构信息

Medtronic plc., 8200 Coral Sea St NE, MS MVN41, 55112, Mounds View, MN, USA.

Cedars-Sinai Heart Institute, Los Angeles, USA.

出版信息

Herzschrittmacherther Elektrophysiol. 2016 Sep;27(3):193-212. doi: 10.1007/s00399-016-0450-6. Epub 2016 Sep 8.

Abstract

Ensuring sensing and detection of ventricular tachycardia (VT) and ventricular fibrillation (VF) was a prerequisite for the clinical trials that established the survival benefit of implantable cardioverter defibrillators (ICDs). However, for decades, a high incidence of unnecessary shocks limited patients' and physicians' acceptance of ICD therapy. Oversensing, misclassification of supraventricular tachycardia (SVT) as VT, and self-terminating VT accounted for the vast majority of unnecessary shocks. Medtronic ICDs utilize sensitive baseline settings with minimal blanking periods to ensure accurate sensing of VF, VT, and SVT electrograms. Programmable algorithms reject oversensing caused by far-field R waves, T waves, and non-physiologic signals caused by lead failure. A robust hierarchy of SVT-VT discriminators minimize misclassification of SVT as VT. These features, combined with evidence-based programming, have reduced the 1‑year inappropriate shock rate to 1.5 % for dual-/triple-chamber ICDs and to 2.5 % for single-chamber ICDs.

摘要

确保对室性心动过速(VT)和心室颤动(VF)进行感知和检测是确立植入式心脏复律除颤器(ICD)生存获益的临床试验的一项先决条件。然而,数十年来,不必要电击的高发生率限制了患者和医生对ICD治疗的接受度。过感知、将室上性心动过速(SVT)误分类为VT以及自限性VT占了绝大多数不必要电击的原因。美敦力ICD采用具有最短空白期的敏感基线设置,以确保准确感知VF、VT和SVT电图。可编程算法可抑制由远场R波、T波以及导线故障导致的非生理性信号引起的过感知。强大的SVT-VT鉴别器层级结构可最大程度减少将SVT误分类为VT的情况。这些特性与循证程控相结合,已将双腔/三腔ICD的1年不适当电击率降至1.5%,单腔ICD的该比率降至2.5%。

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