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[小鼠和大鼠受辐照后体力工作能力紊乱的剂量阈值]

[The dosage thresholds for disordered physical work capacity in mice and rats following irradiation].

作者信息

Malakhovskiĭ V N, Mikhaĭlichenko P P

出版信息

Radiobiologiia. 1989 May-Jun;29(3):379-83.

PMID:2762529
Abstract

Physical efficiency of mice and rats at early times following irradiation with doses of 35 to 200 Gy was estimated by the muscle endurance and motor coordination indices. A threshold nature of the effects was exhibited at high doses. For instance, as large as 40 Gy was the dose threshold at which stability in the accomplishment of the known operations was impaired; at 70-100 Gy, the accomplishment decreased down to 50% of the initial level, by the 2nd hour after irradiation, with the subsequent partial restoration; 200 Gy was the threshold dose at which the disturbances were irreversible. These values were also similar to those of the threshold doses at which clinical picture of the affection was changed.

摘要

通过肌肉耐力和运动协调指标评估了小鼠和大鼠在接受35至200 Gy剂量照射后的早期身体效率。高剂量时表现出效应的阈值特性。例如,高达40 Gy是剂量阈值,在该阈值下,完成已知操作的稳定性受到损害;在70-100 Gy时,照射后第2小时完成率降至初始水平的50%,随后部分恢复;200 Gy是干扰不可逆的阈值剂量。这些值也与疾病临床表现发生变化的阈值剂量相似。

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