Franchi F, Seminara P, Codacci-Pisanelli G, Aronne T, Avella A, Bonomo L
Recenti Prog Med. 1989 May;80(5):261-2.
Five patients with oligoarticular rheumatoid arthritis were treated with intra-articular injections of methotrexate and orgotein in the knee joints. The employed dose of the antimetabolite was very low and orgotein was simultaneously administered to prevent local tissues from cytolysis-related damage. Clinical results were fairly good and support the hypothesis that methotrexate may be used intra-articularly as an immunosuppressor rather than at the heavily toxic doses required for a cytostatic effect.
五名少关节型类风湿性关节炎患者接受了膝关节内注射甲氨蝶呤和奥古蛋白的治疗。抗代谢物的使用剂量非常低，同时给予奥古蛋白以防止局部组织受到细胞溶解相关的损伤。临床结果相当良好，支持了甲氨蝶呤可作为免疫抑制剂关节内使用而非以细胞抑制作用所需的高毒性剂量使用这一假设。
