Halsey N A, Berry S, Carrasco P, de Quadros C, Martinez J, Arroyo J J, España V D, Duarte E, Huertas E, Cruz J R
Department of International Health, Johns Hopkins University, Baltimore, Maryland 21205.
Rev Infect Dis. 1989 May-Jun;11 Suppl 3:S631-8. doi: 10.1093/clinids/11.supplement_3.s631.
Ezeject is a plungerless syringe prefilled with lyophilized measles vaccine. Ezeject syringes were compared with standard 3-cc syringes and 10-dose measles vaccine vials in the vaccination of 884 Guatemalan infants 8-23 months of age. Vaccination was performed by experienced vaccinators and by individuals without prior vaccination experience who received 2.5-3 hours of training. The overall seroconversion rate following administration was 96%, regardless of the type of syringe used or of the experience of the vaccinator. No significant adverse events were observed in children vaccinated with the new syringes. Although incomplete emptying was noted in 87% of the Ezeject syringes used, this had no effect on the serologic response to measles vaccine. Aspiration for detection of blood before injection of the vaccine was performed significantly (P less than .001) less frequently with Ezeject than with 3-cc syringes by both experienced and inexperienced personnel. Inexperienced vaccinators administered measles vaccine significantly faster (P less than .001) with Ezeject than with 3-cc syringes, but the times were similar for experienced vaccinators. Ezeject is an acceptable alternative to standard syringes for the administration of measles vaccine. Several design modifications that would improve the handling of the device and eliminate the possibility of its reuse have been suggested.
Ezeject是一种预装冻干麻疹疫苗的无活塞注射器。在对884名8至23个月大的危地马拉婴儿进行疫苗接种时，将Ezeject注射器与标准3毫升注射器和10剂量麻疹疫苗瓶进行了比较。疫苗接种由经验丰富的接种人员以及未接种过疫苗但接受过2.5至3小时培训的人员进行。无论使用何种注射器类型或接种人员的经验如何，接种后的总体血清转化率为96%。在使用新注射器接种疫苗的儿童中未观察到明显的不良事件。尽管在使用的Ezeject注射器中有87%注意到未完全排空，但这对麻疹疫苗的血清学反应没有影响。经验丰富和缺乏经验的人员使用Ezeject注射器在注射疫苗前进行血液抽吸检测的频率均显著低于（P小于0.001）3毫升注射器。缺乏经验的接种人员使用Ezeject注射器接种麻疹疫苗的速度明显快于（P小于0.001）3毫升注射器，但经验丰富的接种人员接种时间相似。Ezeject是用于接种麻疹疫苗的标准注射器的可接受替代品。已经提出了一些设计改进建议，以改善该装置的操作并消除重复使用的可能性。
