Pátek Ondřej, Horáčková Miroslava, Vítová Lenka, Horváth Rudolf, Háček Jaromír, Schück Otto
Vnitr Lek. 2016 Fall;62(7-8):679-83.
The case report shows a surprising presentation of pulmonary granulomatosis with polyangiitis (GPA) through symptoms of diabetes insipidus (DI) with granulomatous infiltration of the pituitary gland. The pituitary hormonal dysfunction as a result of granulomatosis of the pituitary gland is rare. Several studies have demonstrated that the incidence of the pituitary dysfunction reaches approx. 1 % of the patients with GPA. However it is mostly presented in patients with the disease already diagnosed. The patient described by us had no clinical expressions of GPA in the respiratory tract. He presented with polyuria and polydipsia. It was not until a more detailed examination of these symptoms was performed that a focal lung disease was detected and diagnosed as GPA.
diabetes insipidus - granulomatosis with polyangiitis - granulomatous infiltration of the pituitary gland - pituitary hormonal dysfunction.
该病例报告显示，肺肉芽肿性多血管炎（GPA）通过尿崩症（DI）症状以及垂体肉芽肿性浸润呈现出一种令人惊讶的表现形式。垂体肉芽肿导致的垂体激素功能障碍较为罕见。多项研究表明，垂体功能障碍的发生率约为GPA患者的1%。然而，它大多出现在已确诊该疾病的患者中。我们所描述的患者呼吸道没有GPA的临床表现。他表现为多尿和烦渴。直到对这些症状进行更详细的检查后，才发现并诊断出肺部局灶性疾病为GPA。
尿崩症 - 肉芽肿性多血管炎 - 垂体肉芽肿性浸润 - 垂体激素功能障碍
