Varga G, Dobronyi I, Papp M
Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest.
Scand J Gastroenterol. 1989 Jun;24(5):565-70. doi: 10.3109/00365528909093090.
It is well established that repeated injections of the cholecystokinin (CCK) analogue caerulein induce pancreatic hypersecretion and growth, but so far the time-specific development of hypersecretory capacity has not been studied. Rats were given intraperitoneal injections of caerulein (1 microgram/kg) three times daily for 0-7 days. On the day after the last injection a secretory test was performed with the rats under urethane anaesthesia. Subsequently, pancreatic tissue composition was analysed. Basal and caerulein-stimulated secretion rates of fluid and trypsin were elevated after as little as 1 day of caerulein treatment. These values remained significantly greater than those of the controls after 2-7 days' administration of the peptide. Pancreatic tissue hypertrophy (increases in absolute pancreatic weight, protein and trypsin contents, and also in these values normalized to DNA) appeared after 2 days' pretreatment. Tissue growth turned to hyperplasia (increase in tissue DNA content) after 5 days' caerulein administration. We conclude that chronic administration of the CCK analogue caerulein induces adaptation of the pancreas in a sequential order. First, the hypersecretory state appears, followed by hypertrophy, and, finally, pancreatic growth turns into hyperplasia.
众所周知，反复注射胆囊收缩素（CCK）类似物雨蛙肽可诱导胰腺分泌亢进和生长，但迄今为止，尚未研究过分泌亢进能力的时间特异性发展情况。大鼠每天腹腔注射雨蛙肽（1微克/千克），连续注射0至7天。在最后一次注射后的第二天，在乌拉坦麻醉下对大鼠进行分泌试验。随后，分析胰腺组织组成。仅在雨蛙肽治疗1天后，基础和雨蛙肽刺激的液体和胰蛋白酶分泌率就升高了。在给予该肽2至7天后，这些值仍显著高于对照组。胰腺组织肥大（胰腺绝对重量、蛋白质和胰蛋白酶含量增加，以及这些值相对于DNA归一化后也增加）在预处理2天后出现。在给予雨蛙肽5天后，组织生长转变为增生（组织DNA含量增加）。我们得出结论，长期给予CCK类似物雨蛙肽会使胰腺依次发生适应性变化。首先出现分泌亢进状态，随后是肥大，最后胰腺生长转变为增生。
