Miller K D, Keller J B, Stryker M P
Department of Physiology, University of California, San Francisco 94143-0444.
Science. 1989 Aug 11;245(4918):605-15. doi: 10.1126/science.2762813.
The visual cortex of many adult mammals has patches of cells that receive inputs driven by the right eye alternating with patches that receive inputs driven by the left eye. These ocular dominance patches (or "columns") form during early life as a consequence of competition between the activity patterns of the two eyes. A mathematical model of several biological mechanisms that can account for this development is presented. Analysis of this model reveals the conditions under which ocular dominance segregation will occur and determines the resulting patch width. Simulations of the model also exhibit other phenomena associated with early visual development, such as topographic refinement of cortical receptive fields, the confinement of input cell connections to patches, monocular deprivation plasticity including a critical period, and the effect of artificially induced strabismus. The model can be used to predict the results of proposed experiments and to discriminate among various mechanisms of plasticity.
许多成年哺乳动物的视觉皮层中有一些细胞斑块，它们接收由右眼驱动的输入，并与接收由左眼驱动的输入的斑块交替出现。这些眼优势斑块（或“柱”）在生命早期由于两只眼睛活动模式之间的竞争而形成。本文提出了一个可以解释这种发育的几种生物学机制的数学模型。对该模型的分析揭示了眼优势分离发生的条件，并确定了由此产生的斑块宽度。该模型的模拟还展示了与早期视觉发育相关的其他现象，如皮质感受野的地形细化、输入细胞连接局限于斑块、包括关键期在内的单眼剥夺可塑性以及人工诱导斜视的影响。该模型可用于预测拟议实验的结果，并区分各种可塑性机制。
