Suzuki Kunihito, Yajima Kazuhito, Iwasaki Yoshiaki, Yuu Ken, Oohinata Ryouki, Amaki Misato
Dept. of Surgery, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital.
Gan To Kagaku Ryoho. 2016 Sep;43(9):1109-12.
The aim of this study was to clarify the clinical outcomes of staging laparoscopy(SL)for patients with positive peritonealwashing cytology(CY1P0)after S-1 administration.
Since 2007, eight CY1P0 patients who underwent SL after S-1 administration were enrolled. S-1 was administered according to the ACTS-GC and SL was performed after 8 courses of S-1 treatment.
SL was ended with adequate observation of intra-abdominalcavity in allthe patients with a median time of 68 minutes(range: 52-76 minutes). The timing of SL was after 8 courses of S-1 administration in 6 patients, after 11 courses in 1, and 12 courses in 1. Based on the SL results, CY0P0 was attained in 6 patients; CY1P0, in 1 and CY1P1, in 1. For the 6 patients who attained CY0P0, S-1 administration was completed. For the 2 patients who attained CY1P0 and CY1P1, chemotherapy was continued. Only 1 of the patients who attained CY0P0 had peritoneal recurrence 3 months after completion of S-1 administration.
When CY0P0 is detected by using SL, S-1 administration may be completed. More cases need to be studied to determine the suitable courses or timing of S-1 administration for CY0P0 patients.
本研究旨在阐明S-1给药后腹膜冲洗细胞学检查阳性（CY1P0）患者行分期腹腔镜检查（SL）的临床结局。
自2007年起，纳入8例S-1给药后接受SL的CY1P0患者。S-1按照ACTS-GC方案给药，在S-1治疗8个疗程后进行SL。
所有患者均完成了腹腔的充分观察，SL结束，中位时间为68分钟（范围：52 - 76分钟）。SL时间为：6例患者在S-1给药8个疗程后，1例在11个疗程后，1例在12个疗程后。根据SL结果，6例患者达到CY0P0；1例为CY1P0，1例为CY1P1。对于达到CY0P0的6例患者，完成了S-1给药。对于达到CY1P0和CY1P1的2例患者，继续进行化疗。达到CY0P0的患者中只有1例在S-1给药完成后3个月出现腹膜复发。
当通过SL检测到CY0P0时，可完成S-1给药。需要更多病例研究以确定CY0P0患者S-1给药的合适疗程或时间。
