Singapore Immunology Network, A*STAR, Singapore.
Communicable Disease Centre, Institute of Infectious Disease and Epidemiology, Tan Tock Seng Hospital, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
EBioMedicine. 2016 Oct;12:178-188. doi: 10.1016/j.ebiom.2016.09.003. Epub 2016 Sep 7.
Dengue is endemic in tropical countries worldwide and the four dengue virus serotypes often co-circulate. Infection with one serotype results in high titers of cross-reactive antibodies produced by plasmablasts, protecting temporarily against all serotypes, but impairing protective immunity in subsequent infections. To understand the development of these plasmablasts, we analyzed virus-specific B cell properties in patients during acute disease and at convalescence. Plasmablasts were unrelated to classical memory cells expanding in the blood during early recovery. We propose that only a small subset of memory B cells is activated as plasmablasts during repeat infection and that plasmablast responses are not representative of the memory B cell repertoire after dengue infection.
登革热在全球热带国家流行，四种登革病毒血清型经常共同循环。感染一种血清型会导致浆母细胞产生高滴度的交叉反应性抗体，暂时保护免受所有血清型的感染，但会损害随后感染的保护性免疫。为了了解这些浆母细胞的发展，我们在急性疾病和恢复期分析了患者中病毒特异性 B 细胞的特性。浆母细胞与在早期恢复期间在血液中扩增的经典记忆细胞无关。我们提出，只有一小部分记忆 B 细胞在重复感染时作为浆母细胞被激活，并且浆母细胞反应不能代表登革热感染后的记忆 B 细胞库。
