Wang Wen-Biao, Yang Lai-Fu, He Qing-Song, Li Tong, Ma Yi-Yong, Zhang Ping, Cao Yi-Sheng
Department of Rehabilitation, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
Department of Neurology, the First Affiliated Hospital of Xinxiang Medical College, Weihui, Henan Province, China.
Neural Regen Res. 2016 Jul;11(7):1099-101. doi: 10.4103/1673-5374.187042.
Electroacupuncture at the head acupoints Baihui (GV20) and Shuigou (GV26) improves recovery of neurological function following ischemic cerebrovascular events, but its mechanism remains incompletely understood. We hypothesized that the action of electroacupuncture at these acupoints is associated with elevated serum levels of transforming growth factor beta 1 (TGF-β1). To test this, we established a rat model of cerebral ischemia by middle cerebral artery occlusion. Electroacupuncture was performed at Baihui and Shuigou with a "disperse-dense" wave at an alternating frequency of 2 and 150 Hz, and at a constant intensity of 3 mA. Each electroacupuncture session lasted 30 minutes and was performed every 12 hours for 3 days. Neurological severity scores were lower in injured rats after acupuncture than in those not subjected to treatment. Furthermore, serum level of TGF-β1 was greater after electroacupuncture than after no treatment. Our results indicate that electroacupuncture at Baihui and Shuigou increases the serum level of TGF-β1 in rats with acute cerebral ischemia/reperfusion injury, and exerts neuroprotective effects.
针刺头部穴位百会（GV20）和水沟（GV26）可改善缺血性脑血管事件后神经功能的恢复，但其机制尚不完全清楚。我们推测针刺这些穴位的作用与血清转化生长因子β1（TGF-β1）水平升高有关。为了验证这一点，我们通过大脑中动脉闭塞建立了大鼠脑缺血模型。以2和150Hz的交替频率、3mA的恒定强度，在百会和水沟穴进行“疏密波”电针治疗。每次电针治疗持续30分钟，每12小时进行一次，共3天。针刺后损伤大鼠的神经严重程度评分低于未治疗的大鼠。此外，电针治疗后血清TGF-β1水平高于未治疗组。我们的结果表明，针刺百会和水沟可提高急性脑缺血/再灌注损伤大鼠血清TGF-β1水平，并发挥神经保护作用。
