弓形虫感染与经前烦躁障碍：一项横断面研究。
Toxoplasma gondii Infection and Premenstrual Dysphoric Disorder: A Cross-Sectional Study.
作者信息
Alvarado-Esquivel Cosme, Sanchez-Anguiano Luis Francisco, Hernandez-Tinoco Jesus, Perez-Alamos Alma Rosa, Rico-Almochantaf Yazmin Del Rosario, Estrada-Martinez Sergio, Vaquera-Enriquez Raquel, Diaz-Herrera Arturo, Ramos-Nevarez Agar, Sandoval-Carrillo Ada Agustina, Salas-Pacheco Jose Manuel, Cerrillo-Soto Sandra Margarita, Antuna-Salcido Elizabeth Irasema, Liesenfeld Oliver, Guido-Arreola Carlos Alberto
机构信息
Faculty of Medicine and Nutrition, Juarez University of Durango State, Avenida Universidad S/N, 34000 Durango, Dgo, Mexico.
Institute for Scientific Research "Dr. Roberto Rivera Damm", Juarez University of Durango State, Avenida Universidad S/N, 34000 Durango, Durango, Mexico.
出版信息
J Clin Med Res. 2016 Oct;8(10):730-6. doi: 10.14740/jocmr2699w. Epub 2016 Aug 30.
BACKGROUND
Premenstrual dysphoric disorder is a severe form of premenstrual syndrome. The influence of Toxoplasma gondii (T. gondii) infection on clinical features in women with this disorder has not been studied. Therefore, we determined the association of T. gondii infection with symptoms and signs in women suffering from premenstrual dysphoric disorder.
METHODS
We performed a cross-sectional study of 151 women suffering from premenstrual dysphoric disorder. Anti-Toxoplasma IgG and IgM antibodies were detected in sera of the participants using enzyme-linked immunoassays (EIAs). In addition, T. gondii DNA was detected in whole blood of IgG seropositive participants using polymerase chain reaction. We obtained the clinical data of women with the aid of a questionnaire. The association of T. gondii infection with clinical characteristics of women was assessed by bivariate and multivariate analyses.
RESULTS
Anti-T. gondii IgG antibodies were found in 10 (6.6%) of the 151 women studied. Of the 10 IgG seropositive women, four (40.0%) were positive for anti-T. gondii IgM antibodies, and one (10.0%) for T. gondii DNA. Mean number (25.8 ± 7.58) of premenstrual clinical characteristics in seropositive women was similar to that (29.22 ± 9.13) found in seronegative women (P = 0.25). Logistic regression showed that seropositivity to T. gondii was negatively associated with difficulty concentrating (OR: 0.18; 95% CI: 0.03 - 0.91; P = 0.03), and positively associated with out of control feeling or overwhelmed (OR: 9.00; 95% CI: 1.32 - 62.00; P = 0.02).
CONCLUSIONS
Results of this first study on the association of T. gondii infection and clinical characteristics of premenstrual dysphoric disorder suggest that this infection might be linked to some symptoms of this disorder. We report for the first time the association of T. gondii infection and out of control feeling or overwhelmed. Results warrant for further research on the role of T. gondii in premenstrual dysphoric disorder.
背景
经前烦躁障碍是经前综合征的一种严重形式。弓形虫感染对患有这种疾病的女性临床特征的影响尚未得到研究。因此，我们确定了弓形虫感染与经前烦躁障碍女性症状和体征之间的关联。
方法
我们对151名经前烦躁障碍女性进行了一项横断面研究。使用酶联免疫吸附测定（ELISA）检测参与者血清中的抗弓形虫IgG和IgM抗体。此外，使用聚合酶链反应在IgG血清阳性参与者的全血中检测弓形虫DNA。我们通过问卷调查获得了这些女性的临床数据。通过双变量和多变量分析评估弓形虫感染与女性临床特征之间的关联。
结果
在151名研究女性中，有10名（6.6%）检测出抗弓形虫IgG抗体。在这10名IgG血清阳性女性中，4名（40.0%）抗弓形虫IgM抗体呈阳性，1名（10.0%）弓形虫DNA呈阳性。血清阳性女性经前临床特征的平均数量（25.8±7.58）与血清阴性女性（29.22±9.13）相似（P = 0.25）。逻辑回归显示，弓形虫血清阳性与注意力不集中呈负相关（比值比：0.18；95%置信区间：0.03 - 0.91；P = 0.03），与失控感或不堪重负呈正相关（比值比：9.00；95%置信区间：1.32 - 62.00；P = 0.02）。
结论
这项关于弓形虫感染与经前烦躁障碍临床特征关联的首次研究结果表明，这种感染可能与该疾病的某些症状有关。我们首次报告了弓形虫感染与失控感或不堪重负之间的关联。这些结果值得对弓形虫在经前烦躁障碍中的作用进行进一步研究。
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