Zwingenberger W, Nestler K, Faulhaber H D, Schneider R
Gesundheitswesen Wismut, Akademie der Wissenschaften der DDR Berlin-Buch.
Z Gesamte Inn Med. 1989 May 15;44(10):296-300.
82 hypertensive patients with a prescription of medicaments of three and more individual doses a day who worked in the three-shift system were anonymously asked about their behaviour concerning the intake of tablets. 78% said not to have obtained any recommendations for the intake of tablets during the nightwork. 20.7% of them took antihypertensive drugs at night during the shift. 51.3% in the day-time and 28.0% did not take any tablets during the night-work. The compliance was approximately 60%, similarly as in hypertensive patients working in the one-shift system. With 3.7% the non-compliance was lowest during the night-shift. It was 22.0% during the early shift and 12.1% during the late shift. Side-effects and disturbances of the good health, respectively, during the antihypertensive treatment were stated with 14.0% and with 7.3% they appeared most frequently during the night-work. There was a statistically ascertained connection between the intake of tablets at night during work and the side-effects. They altogether appeared more infrequently, when a concrete advice was given by the physician. From this is concluded that on principle in shift-workers a treatment of the hypertension is to be aspired to with one or two individual doses a day, otherwise in a prescription of three individual doses the tablets should not be taken at night during work, but in the day-time. The temporary intake of tablets during shift-work as well as possible side-effects and corresponding behaviour patterns when disturbances of good health are appearing are to be discussed in detail particularly with the three-shift workers.(ABSTRACT TRUNCATED AT 250 WORDS)
82名每天需服用三种及以上不同剂量药物的高血压患者在三班制工作,他们被匿名询问服药行为。78%的人表示在夜班期间未获得任何服药建议。其中20.7%的人在夜班期间服用降压药。51.3%的人在白天服药,28.0%的人在夜班期间不服药。依从性约为60%,与单班制工作的高血压患者相似。夜班期间的不依从率最低,为3.7%。早班期间为22.0%,晚班期间为12.1%。降压治疗期间分别有14.0%的人出现副作用,7.3%的人在夜班期间出现副作用的频率最高。工作期间夜间服药与副作用之间存在统计学上确定的关联。当医生给出具体建议时,副作用总体出现得更不频繁。由此得出结论,原则上对于轮班工作的高血压患者,应争取每天服用一或两种不同剂量的药物进行治疗,否则在开三种不同剂量的处方时,不应在工作期间的夜间服药,而应在白天服药。尤其应与三班制工人详细讨论轮班工作期间临时服药的情况以及健康出现问题时可能出现的副作用和相应行为模式。(摘要截选至250字)