Samalin Ludovic, de Chazeron Ingrid, Blanc Olivier, Brunel Lore, Fond Guillaume, Llorca Pierre-Michel
CHU Clermont-Ferrand, University of Auvergne, EA 7280, Clermont-Ferrand, France; Fondation FondaMental, Créteil, France.
CHU Clermont-Ferrand, University of Auvergne, EA 7280, Clermont-Ferrand, France.
Schizophr Res. 2016 Dec;178(1-3):1-5. doi: 10.1016/j.schres.2016.09.015. Epub 2016 Sep 13.
To investigate the interest in the attitudes toward antipsychotic medication in exploring medication non-adherence.
Schizophrenic patients (N=120) completed the Beliefs about Medicines Questionnaire and measures of medication adherence, and clinical outcomes. Comparison between four attitudinal groups and logistic regressions were performed.
High level of adherence varied significantly between attitudinal groups (Accepting, 70%; Indifferent, 63%; Ambivalent, 50%; Sceptical, 14%; p<0.001). Poor insight and psychic side effects were the most significant predictors of negative beliefs.
The attitudinal groups approach could facilitate the identification of patients with non-adherence and determine individual targets of interventions to improve negative beliefs.
在探索药物治疗不依从性时，调查对抗精神病药物态度的兴趣。
120名精神分裂症患者完成了《药物信念问卷》、药物依从性测量及临床结果评估。对四个态度组进行了比较并进行了逻辑回归分析。
态度组之间的高依从性水平差异显著（接受组，70%；冷漠组，63%；矛盾组，50%；怀疑组，14%；p<0.001）。洞察力差和精神副作用是负面信念最显著的预测因素。
态度组方法有助于识别不依从患者，并确定改善负面信念的个体干预目标。
