Dahl R, Puig-Antich J, Ryan N, Nelson B, Novacenko H, Twomey J, Williamson D, Goetz R, Ambrosini P J
Department of Child Psychiatry, New York State Psychiatric Institute, New York.
Acta Psychiatr Scand. 1989 Jul;80(1):18-26. doi: 10.1111/j.1600-0447.1989.tb01295.x.
Plasma cortisol concentrations were determined every 20 min for 24 h, in a nonstressful environment, among 48 rigorously assessed, mostly outpatient, drug-free adolescent subjects during an episode of major depression (MDD) and among 40 normal adolescent subjects. There were no significant differences in the 24-h mean, peak, or nadir, or the time of the nocturnal rise, in plasma cortisol in the 2 groups. Analyses of different subgroups of MDD adolescents according to suicidality, severity of depression, separation anxiety, psychotic subtype, endogenicity, duration of episode, and sex also revealed no significant group differences. Only one adolescent (with MDD) was identified clearly as a hypersecretor of cortisol. These results indicate that abnormalities of spontaneous cortisol secretion are an unusual finding among adolescents with major depression when studied in a nonstressful environment.
在无压力环境下，对48名经过严格评估、大多为门诊患者且未服用药物的青少年重度抑郁症（MDD）发作期患者以及40名正常青少年进行了24小时监测，每20分钟测定一次血浆皮质醇浓度。两组患者的血浆皮质醇24小时均值、峰值或谷值以及夜间升高时间均无显著差异。根据自杀倾向、抑郁严重程度、分离焦虑、精神病亚型、内源性、发作持续时间和性别对MDD青少年不同亚组进行分析，也未发现显著的组间差异。仅一名（患有MDD的）青少年被明确鉴定为皮质醇分泌过多者。这些结果表明，在无压力环境下研究时，青少年重度抑郁症患者中自发性皮质醇分泌异常是一个不常见的发现。
