McIntosh C J, Davis P F, Ryan P A, Stehbens W E
Malaghan Institute of Medical Research, Wellington School of Medicine, Wellington Hospital, New Zealand.
Angiology. 1989 Sep;40(9):814-7. doi: 10.1177/000331978904000907.
In diseases of major arteries there is an increased turnover of connective tissue components. This implies a greater excretion of fragments of collagen and elastin. The changes for each of these may be useful in further delineating the nature of the disease. In a preliminary study, the urine of 10 Marfan's syndrome patients was analyzed. The hydroxyproline (collagen) concentration was up to eight times higher than that of control subjects. The desmosine (elastin) crosslink concentration was either normal or slightly reduced in these patients. The mean of the ratio of hydroxyproline to desmosine was nearly seven times higher in the patients.
在大动脉疾病中，结缔组织成分的更新加快。这意味着胶原蛋白和弹性蛋白片段的排泄增加。这些成分各自的变化可能有助于进一步明确疾病的性质。在一项初步研究中，对10名马凡综合征患者的尿液进行了分析。羟脯氨酸（胶原蛋白）浓度比对照受试者高出多达8倍。这些患者的锁链素（弹性蛋白）交联浓度正常或略有降低。患者中羟脯氨酸与锁链素的平均比值高出近7倍。
