Park Jaekyoung, Shin Hyejin, Song Haengseok, Lim Hyunjung J
Department of Biomedical Science & Technology, Konkuk University, Seoul, Republic of Korea.
Department of Biomedical Science, CHA University, Seongnam, Republic of Korea.
Steroids. 2016 Nov;115:177-181. doi: 10.1016/j.steroids.2016.09.011. Epub 2016 Sep 16.
Two female sex steroid hormones, estrogen and progesterone, are crucial regulators of many physiological functions of reproductive organs. These two hormones are versatile factors linking growth, differentiation, metabolism, and death of cells in the uterus. In recent years, it has become evident that autophagy is involved in the effects of estrogen and progesterone on various cellular events in reproductive organs. Autophagy is the self-eating catabolic process which is linked to cell survival and death in many contexts. In this review, we focus on the new findings concerning the regulation of autophagic response by sex steroid hormones in responsive target organs. We also attempt to further expand our insight into intracellular signaling mediators governing this regulation.
雌激素和孕激素这两种女性性甾体激素是生殖器官许多生理功能的关键调节因子。这两种激素是连接子宫细胞生长、分化、代谢和死亡的多能因子。近年来，有证据表明自噬参与了雌激素和孕激素对生殖器官各种细胞事件的影响。自噬是一种自我吞噬的分解代谢过程，在许多情况下与细胞存活和死亡相关。在本综述中，我们重点关注性甾体激素在反应性靶器官中对自噬反应调节的新发现。我们还试图进一步深入了解控制这种调节的细胞内信号介质。
