Kuhli-Hattenbach C, Hellstern P, Miesbach W, Kohnen T, Hattenbach L-O
Klinik für Augenheilkunde, Klinikum der Johann Wolfgang Goethe-Universität Frankfurt.
Institut für Hämostaseologie und Transfusionsmedizin, Klinikum der Stadt Ludwigshafen gGmbH.
Klin Monbl Augenheilkd. 2018 Jan;235(1):81-86. doi: 10.1055/s-0042-114041. Epub 2016 Sep 19.
The potential impact of elevated Lipoprotein (a) [Lp(a)] levels on retinal venous occlusive (RVO) diseases with regard to age and various risk factors has not been studied extensively.
In a retrospective case-control study, thrombophilia data of 106 young patients (< 60 years at the time of the RVO or a previous thromboembolic event) with RVO and 76 healthy subjects were evaluated.
Elevated Lp(a) plasma levels were significantly more prevalent among RVO patients (29.2 %) than among controls (9.2 %; p = 0.0009). Lp(a) levels were found to be significantly (p = 0.012) different between patients and controls. Moreover, we found that an unusual personal or family history of thromboembolism was a strong predictor of elevated Lp(a) (p = 0.03). We observed a significant correlation between elevated Lp(a) and other coagulation disorders (p = 0.005). Multivariate analysis showed that elevated lipoprotein(a) levels (OR: 3.5; p = 0.003) were an independent risk factor for the development of RVO.
Elevated plasma levels of Lp(a) are associated with the development of RVO. Selective screening of young patients and subjects with a personal or family history of thromboembolism may be helpful in identifying RVO patients with elevated Lp(a).
关于脂蛋白(a)[Lp(a)]水平升高对视网膜静脉阻塞(RVO)疾病在年龄和各种风险因素方面的潜在影响，尚未进行广泛研究。
在一项回顾性病例对照研究中，对106例患有RVO的年轻患者（RVO或既往血栓栓塞事件发生时年龄<60岁）和76名健康受试者的血栓形成倾向数据进行了评估。
RVO患者中Lp(a)血浆水平升高的情况（29.2%）明显比对照组（9.2%）更普遍（p = 0.0009）。发现患者和对照组之间Lp(a)水平存在显著差异（p = 0.012）。此外，我们发现不寻常的个人或家族血栓栓塞病史是Lp(a)升高的有力预测指标（p = 0.03）。我们观察到Lp(a)升高与其他凝血障碍之间存在显著相关性（p = 0.005）。多变量分析显示，脂蛋白(a)水平升高（比值比：3.5；p = 0.003）是RVO发生的独立危险因素。
Lp(a)血浆水平升高与RVO的发生有关。对年轻患者以及有个人或家族血栓栓塞病史的受试者进行选择性筛查，可能有助于识别Lp(a)升高的RVO患者。
