Dow Caitlin A, Lincenberg Grace M, Greiner Jared J, Stauffer Brian L, DeSouza Christopher A
a Integrative Vascular Biology Laboratory, Department of Integrative Physiology, University of Colorado, Boulder, CO 80309, USA.
b Department of Medicine, University of Colorado Denver and the Health Sciences Center, Aurora, CO 80045, USA.
Appl Physiol Nutr Metab. 2016 Oct;41(10):1013-1017. doi: 10.1139/apnm-2016-0171. Epub 2016 May 25.
Metabolic syndrome (MetS) typically presents with obesity; however, obesity is not a requisite characteristic for MetS classification and related vascular risk. We tested the hypothesis that MetS, independent of excess adiposity, is associated with impaired endothelial vasodilator dysfunction. Thirty-two sedentary, middle-aged adults were studied: 11 normal weight (9 male and 2 female; body mass index (BMI), 24.0 ± 0.3 kg/m); 11 normal weight with MetS (9 male and 2 female; BMI, 24.7 ± 0.3 kg/m); and 10 obese without MetS (8 male and 2 female; BMI, 31.4 ± 0.5 kg/m). MetS was established according to National Cholesterol Education Program Adult Treatment Panel III criteria. Forearm blood flow (FBF) responses to intra-arterial infusions of acetylcholine and sodium nitroprusside were measured via strain-gauge plethysmography. FBF responses to acetylcholine were ∼20% lower (P < 0.05) in the normal-weight subjects with MetS (from 4.0 ± 0.3 to 13.0 ± 1.0 mL/(100 mL tissue·min)) and obese subjects (from 4.8 ± 0.2 to 12.2 ± 1.1 mL/(100 mL tissue·min)) compared with the normal-weight subjects (from 4.6 ± 0.4 to 15.8 ± 0.7 mL/(100 mL tissue·min)). Of note, FBF responses to acetylcholine were similar between the normal-weight adults with MetS and the obese adults. There were no differences among groups in FBF response to sodium nitroprusside. These data indicate that the presence of MetS, independent of obesity, is associated with diminished endothelium-dependent vasodilation. Endothelial vasodilator dysfunction may underlie the increased cardiovascular risk in normal-weight adults with MetS.
代谢综合征（MetS）通常伴有肥胖；然而，肥胖并非MetS分类及相关血管风险的必要特征。我们检验了以下假设：独立于过度肥胖之外，MetS与内皮血管舒张功能障碍有关。对32名久坐不动的中年成年人进行了研究：11名体重正常者（9名男性和2名女性；体重指数（BMI）为24.0±0.3kg/m²）；11名患有MetS的体重正常者（9名男性和2名女性；BMI为24.7±0.3kg/m²）；以及10名无MetS的肥胖者（8名男性和2名女性；BMI为31.4±0.5kg/m²）。根据美国国家胆固醇教育计划成人治疗小组第三次报告的标准确定是否患有MetS。通过应变片体积描记法测量前臂血流量（FBF）对动脉内注入乙酰胆碱和硝普钠的反应。与体重正常的受试者（从4.6±0.4至15.8±0.7mL/（100mL组织·分钟））相比，患有MetS的体重正常受试者（从4.0±0.3至13.0±1.0mL/（100mL组织·分钟））和肥胖受试者（从4.8±0.2至12.2±1.1mL/（100mL组织·分钟））对乙酰胆碱的FBF反应降低了约20%（P<0.05）。值得注意的是，患有MetS的体重正常成年人与肥胖成年人对乙酰胆碱的FBF反应相似。各组对硝普钠的FBF反应没有差异。这些数据表明，独立于肥胖之外，MetS的存在与内皮依赖性血管舒张减弱有关。内皮血管舒张功能障碍可能是患有MetS的体重正常成年人心血管风险增加的基础。
