Dong Lian-hua, Ran Mao-liang, Li Zhi, Peng Fu-zhi, Chen Bin
1. College of Animal Science & Technology, Hunan Agricultural University, Changsha 410128, China; 2. Hunan Provincial Key Laboratory for Genetic Improvement of Domestic Animal, Changsha 410128, China.
Yi Chuan. 2016 Sep;38(9):791-800. doi: 10.16288/j.yczz.16-120.
Ubiquitin-proteasome pathway (UPP) is the main pathway of protein degradation in eukaryotic cells. The UPP plays very important roles in cell cycle progression, apoptosis, stress response and growth and development through regulating protein interaction, protein activity, protein localization and signal transduction. Previous studies have shown that the UPP is essential for regulating acrosome and tail biogenesis during spermatogenesis in human and animals. The dysregulation of UPP during spermatogenesis results in sperm deformity and reduced sperm motility and leads to reproductive system diseases such as oligospermatism, infertility and testicular tumors. In this review, we summarized the signal transduction and regulation mechanism of UPP in spermatogenesis, which may provide references for future studies.
泛素-蛋白酶体途径（UPP）是真核细胞中蛋白质降解的主要途径。UPP通过调节蛋白质相互作用、蛋白质活性、蛋白质定位和信号转导，在细胞周期进程、细胞凋亡、应激反应以及生长发育中发挥着非常重要的作用。先前的研究表明，UPP对于调节人和动物精子发生过程中的顶体和尾部生物合成至关重要。精子发生过程中UPP的失调会导致精子畸形和精子活力降低，并引发少精子症、不育症和睾丸肿瘤等生殖系统疾病。在本综述中，我们总结了UPP在精子发生中的信号转导和调控机制，这可能为未来的研究提供参考。
