Lordick Florian, Terashima Masanori
University Cancer Center Leipzig (UCCL), University Hospital Leipzig, Liebigstr. 20, 04103, Leipzig, Germany.
Division of Gastric Surgery, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan.
Best Pract Res Clin Gastroenterol. 2016 Aug;30(4):581-91. doi: 10.1016/j.bpg.2016.06.006. Epub 2016 Jul 1.
From a global perspective, gastric cancer is one of the most common and lethal forms of cancer. The incidence of gastric cancer is very high in East Asia and varies considerably in countries of the Western hemisphere. Even after curative resection, the relapse rates are high in stages II and III. Therefore, adjuvant treatment with chemotherapy has been studied with positive results, especially in East Asian populations. In the Western World, where many locally advanced and borderline resectable gastric cancers are diagnosed, perioperative chemotherapy has become a standard of care. Perioperative chemotherapy increases the chances for curative resection. The additional role of radiation therapy, either in the neoadjuvant or in the adjuvant setting, needs to be defined by studies with a quality assurance for all treatment modalities.
从全球角度来看，胃癌是最常见且致命的癌症形式之一。东亚地区胃癌发病率很高，而西半球各国的发病率差异很大。即使进行了根治性切除，II期和III期患者的复发率仍很高。因此，对辅助化疗进行了研究并取得了积极成果，尤其是在东亚人群中。在西方世界，许多局部晚期和可切除边缘的胃癌被诊断出来，围手术期化疗已成为一种标准治疗方法。围手术期化疗增加了根治性切除的机会。放疗在新辅助或辅助治疗中的额外作用，需要通过对所有治疗方式进行质量保证的研究来确定。
