Rao K S, Hannart J A, Trouet A
S.A IRE-CELLTARG, Fleurus, Belgium.
Anticancer Res. 1989 May-Jun;9(3):619-24.
Vinblastine-C4 acyl derivatives were synthesized by linking alkyl maleoyl or amino acid maleoyl compounds through an ester linkage at the C4 position of the vindoline moiety of vinblastine. The condensation of the above mentioned compounds was performed by the mixed anhydride method. Their synthesis, yields and physiochemical data are reported.
长春碱 - C4 酰基衍生物是通过将烷基马来酰或氨基酸马来酰化合物在长春碱长春质部分的 C4 位通过酯键连接而合成的。上述化合物的缩合反应采用混合酸酐法进行。报道了它们的合成、产率及理化数据。
