Linseman M A
Biobehavioral Research Department, Addiction Research Foundation, Toronto, Canada.
Appetite. 1989 Apr;12(2):153-9. doi: 10.1016/0195-6663(89)90104-9.
A number of different studies have suggested that the amount of alcohol consumed in a single bout by free-feeding rats is regulated by its pharmacological consequences. The present experiments were designed to test the limits of this apparent pharmacological regulation by examining the effect of weight restriction and enhanced palatability, two variables that have been shown to increase alcohol consumption when the alcohol is continuously available, on amount of alcohol consumed in a single bout. Increasing the palatability of the alcohol solution by the addition of saccharin enhanced consumption substantially such that the blood alcohol levels (BALS) achieved were more than twice those of animals which had drunk unadulterated alcohol. Weight restriction to 80% of free-feeding weight (FFW), however, did not increase alcohol consumption under these conditions. The similarity between these results and those obtained in studies of the regulation of feeding are discussed.
许多不同的研究表明，自由进食的大鼠单次饮酒量受其药理作用的调节。本实验旨在通过研究体重限制和适口性增强这两个变量对单次饮酒量的影响，来测试这种明显的药理调节的限度。当酒精持续供应时，这两个变量已被证明会增加酒精摄入量。通过添加糖精提高酒精溶液的适口性，可大幅增加酒精摄入量，使得所达到的血液酒精浓度（BALs）是饮用未掺假酒精的动物的两倍以上。然而，在这些条件下，将体重限制在自由进食体重（FFW）的80%并不会增加酒精摄入量。文中讨论了这些结果与进食调节研究结果之间的相似性。
