Singh Gopal, Coffey Amy, Neely Robert, Lambert Daniel, Sonett Joshua, Borczuk Alain C, Gorenstein Lyall
Section of Thoracic Surgery, Columbia University Medical Center, New York, New York.
Department of Pathology, Columbia University Medical Center, New York, New York.
Ann Thorac Surg. 2016 Oct;102(4):e335-7. doi: 10.1016/j.athoracsur.2016.01.104.
Congenital pulmonary airway malformation (CPAM) is a developmental abnormality of the lung, which results from an abnormality of branching during fetal development of the lung. We report the case of an 18 year-old woman who developed Kirsten rat sarcoma virus (KRAS) mutation positive mucinous adenocarcinoma of the lung (AC) in association with mixed CPAM type 1 and 2. This case is unique as KRAS mutation positive AC is present in a setting of both CPAM 1 and 2 in the same lesion.
先天性肺气道畸形（CPAM）是一种肺部发育异常，由胎儿期肺发育过程中的分支异常引起。我们报告了一例18岁女性病例，该患者发生了 Kirsten 大鼠肉瘤病毒（KRAS）突变阳性的肺黏液腺癌（AC），同时合并1型和2型混合型 CPAM。该病例独特之处在于，在同一病变中，KRAS 突变阳性的 AC 同时存在于 CPAM 1和2的情况下。
