Rumalla Kavelin, Gondi Keerthi T, Reddy Adithi Y, Mittal Manoj K
a University of Missouri-Kansas City School of Medicine , Kansas City , MO , USA.
b Department of Neurology , University of Kansas Medical Center , Kansas City , KS , USA.
Int J Neurosci. 2017 Apr;127(4):326-333. doi: 10.1080/00207454.2016.1239196. Epub 2016 Oct 13.
The goal of our study was to determine if patients with Parkinson's disease (PD) are more susceptible to hospitalization for traumatic brain injury (TBI).
The US Nationwide Inpatient Sample database was queried (2004-2011) to identify cohorts of patients with PD (N = 1 047 656) and without PD (N = 115 95 173). The age range of the study population was 60-89 years. The incidence of TBI among patients with PD was compared to the incidence of TBI in patients without PD. A multivariate logistic regression model, adjusted for all covariates that significantly differed in the bivariate analyses, was used to determine if PD was an independent predictor of TBI hospitalization.
The incidence of TBI hospitalization was significantly higher (relative risk: 1.76, 95% CI: 1.73-1.80) in the PD cohort. The PD cohort with TBI had fewer comorbidities and risk factors for falls/TBI compared to the non-PD cohort with TBI. The multivariable analysis, adjusting for other TBI risk factors, revealed that PD status increased the likelihood of TBI hospitalization (odds ratio: 2.99, 95% CI: 2.93-3.05).
Our study shows that patients with PD are more susceptible to hospitalization for TBI. A greater proportion of fall-related TBI occurs in patients with PD compared to patients without PD. Further research is needed to prevent falls in PD patients to avoid TBI.
我们研究的目的是确定帕金森病（PD）患者是否更容易因创伤性脑损伤（TBI）而住院。
查询美国全国住院患者样本数据库（2004 - 2011年），以确定PD患者队列（N = 1047656）和非PD患者队列（N = 11595173）。研究人群的年龄范围为60 - 89岁。将PD患者中TBI的发生率与非PD患者中TBI的发生率进行比较。使用多变量逻辑回归模型，对双变量分析中显著不同的所有协变量进行调整，以确定PD是否是TBI住院的独立预测因素。
PD队列中TBI住院的发生率显著更高（相对风险：1.76，95%置信区间：1.73 - 1.80）。与患有TBI的非PD队列相比，患有TBI的PD队列的合并症和跌倒/TBI的风险因素更少。在对其他TBI风险因素进行调整的多变量分析中，发现PD状态增加了TBI住院的可能性（优势比：2.99，95%置信区间：2.93 - 3.05）。
我们的研究表明，PD患者更容易因TBI而住院。与非PD患者相比，PD患者中与跌倒相关的TBI发生率更高。需要进一步研究以预防PD患者跌倒，避免TBI。
