Ihenacho H N, Magulike E
Department of Medicine, University of Nigeria Teaching Hospital, Enugu.
Aust N Z J Med. 1989 Feb;19(1):17-21. doi: 10.1111/j.1445-5994.1989.tb01666.x.
Twelve of 30 Africans with heart block gave a history of chronic chloroquine abuse. Eleven of these had evidence of chloroquine retinopathy whereas four of the 18 nonabusers had abnormal ophthalmologic findings, thought to be senile changes. The chronic chloroquine abusers were all male and were younger (mean age 51.6 years) than the non-abusers (mean age 61.2), nine of whom were female. Serum chloroquine levels were not helpful diagnostically. In the absence of other etiological factors, chronic chloroquine toxicity is important in the causation of heart block in Africans.
30名患有心脏传导阻滞的非洲人中，有12人有长期滥用氯喹的病史。其中11人有氯喹视网膜病变的证据，而18名未滥用者中有4人有异常的眼科检查结果，被认为是老年性改变。长期滥用氯喹者均为男性，且比未滥用者年轻（平均年龄51.6岁），未滥用者平均年龄61.2岁，其中9人为女性。血清氯喹水平对诊断没有帮助。在没有其他病因的情况下，慢性氯喹中毒在非洲人心脏传导阻滞的病因中很重要。
