Buchanan P, Convertino V A
Biomedical Operations and Research Office, NASA, Kennedy Space Center, FL 32899.
Aviat Space Environ Med. 1989 Jul;60(7):649-52.
The reduction of muscle strength and size of the lower extremities has been observed following spaceflight. However, there are virtually no data from direct measurements of muscle tissue which provide a means of understanding the physiological alterations associated with the impaired function. We therefore conducted a study in which eight healthy men underwent 30 days of continuous exposure to 6 degrees headdown tilt as an analogue for space microgravity. We used percutaneous muscle biopsy, computed tomography, anthropometry, and in vivo muscle strength measures under controlled experimental conditions to provide new data about mechanical, structural, and metabolic characteristics of skeletal muscle in man following exposure to microgravity.
航天飞行后观察到下肢肌肉力量和尺寸有所下降。然而，几乎没有来自肌肉组织直接测量的数据，这些数据能为理解与功能受损相关的生理改变提供一种方法。因此，我们开展了一项研究，让8名健康男性连续30天暴露于6度头低位倾斜，以此模拟太空微重力环境。我们在可控的实验条件下，采用经皮肌肉活检、计算机断层扫描、人体测量学以及体内肌肉力量测量方法，来提供有关人体骨骼肌在暴露于微重力环境后的力学、结构和代谢特征的新数据。
