采用不平衡波形的电神经刺激可减轻铂电极的溶解。
Electrical neurostimulation with imbalanced waveform mitigates dissolution of platinum electrodes.
作者信息
Kumsa Doe, Hudak Eric M, Montague Fred W, Kelley Shawn C, Untereker Darrel F, Hahn Benjamin P, Condit Chris, Cholette Martin, Lee Hyowon, Bardot Dawn, Takmakov Pavel
机构信息
Division of Biology, Chemistry, and Materials Science, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, US Food and Drug Administration, White Oak Federal Research Center, Silver Spring, MD, USA. Medical Device Innovation Consortium, St. Louis Park, MN, USA.
出版信息
J Neural Eng. 2016 Oct;13(5):054001. doi: 10.1088/1741-2560/13/5/054001. Epub 2016 Sep 21.
OBJECTIVE
Electrical neurostimulation has traditionally been limited to the use of charge-balanced waveforms. Charge-imbalanced and monophasic waveforms are not used to deliver clinical therapy, because it is believed that these stimulation paradigms may generate noxious electrochemical species that cause tissue damage.
APPROACH
In this study, we investigated the dissolution of platinum as one of such irreversible reactions over a range of charge densities up to 160 μC cm with current-controlled first phase, capacitive discharge second phase waveforms of both cathodic-first and anodic-first polarity. We monitored the concentration of platinum in solution under different stimulation delivery conditions including charge-balanced, charge-imbalanced, and monophasic pulses.
MAIN RESULTS
We observed that platinum dissolution decreased during charge-imbalanced and monophasic stimulation when compared to charge-balanced waveforms.
SIGNIFICANCE
This observation provides an opportunity to re-evaluate the charge-balanced waveform as the primary option for sustainable neural stimulation.
目的
传统上，电神经刺激仅限于使用电荷平衡波形。电荷不平衡和单相波形不用于提供临床治疗，因为人们认为这些刺激模式可能会产生有害的电化学物质，从而导致组织损伤。
方法
在本研究中，我们研究了在高达160 μC/cm的一系列电荷密度范围内，铂的溶解情况，该溶解是作为一种不可逆反应，采用阴极优先和阳极优先极性的电流控制第一阶段、电容放电第二阶段波形。我们监测了在不同刺激传递条件下溶液中铂的浓度，这些条件包括电荷平衡、电荷不平衡和单相脉冲。
主要结果
我们观察到，与电荷平衡波形相比，在电荷不平衡和单相刺激过程中铂的溶解减少。
意义
这一观察结果为重新评估电荷平衡波形作为可持续神经刺激的主要选择提供了机会。
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