Phillipps Clélie, Kemp Jennifer, Jacob Christel, Veronneau Alyssa, Albasser Timothée, Philippi Nathalie, Cretin Benjamin, Bernard Frédéric, Blanc Frédéric
Hôpitaux universitaires de Strasbourg, Centre mémoire de ressources et de recherche (CMRR), service de neurologie, unité de neuropsychologie, Strasbourg, France, Hôpitaux universitaires de Strasbourg, Hôpital de jour, Centre mémoire de ressources et de recherche (CMRR), Pôle de gériatrie, Strasbourg, France.
Centre hospitalier de Nancy, unité cognitivo-comportementale ; Laboratoire InterPsy, EA4432, Groupe de recherche sur les communications, Université de Lorraine, Nancy, France.
Geriatr Psychol Neuropsychiatr Vieil. 2016 Sep 1;14(3):332-40. doi: 10.1684/pnv.2016.0620.
The production of false memories (FMs) is a normal phenomenon, which can be affected in neurodegenerative diseases such as Alzheimer's disease (AD). Only few studies investigated FMs in patients with dementia with Lewy bodies (DLB). The aim of our preliminary study was to assess FMs in patients with DLB and to identify the underlying cognitive deficits influencing the production of FMs in DLB and AD. Ten AD patients and nine DLB patients performed a memory task (free recall and recognition) coupling two paradigms, namely the DRM (Deese-Roediger-McDermott) paradigm, promoting the production of FMs and the "Remember/Know" (R/K) paradigm, allowing to investigate the phenomenological experience during the recollection of a memory. A standard cognitive evaluation of memory, executive and instrumental functions completed the assessment. No FM was found in the DLB group during free recall, while the number of FMs was substantially identical in both groups during recognition. However, FMs differed from the phenomenological experience, with more K responses in DLB patients and more R responses in AD patients. None of the tests of the standard neuropsychological evaluation did correlate with measures of interest of FMs. In AD patients, the R responses associated with FMs reflect an alteration of the source memory. In DLB patients, the critical item lead to a sense of familiarity, without recollection of the circumstances in which the item was encoded, hence the K responses. This indicates a preservation of their source memory. Contrary to expectations, the type of FMs in both groups was not correlated to their cognitive profile. Hence, cognitive processes underlying the FMs appear to be different in AD and the LBD, but FMs seem independent of memory and executive abilities in these diseases.
错误记忆（FMs）的产生是一种正常现象，在诸如阿尔茨海默病（AD）等神经退行性疾病中可能会受到影响。仅有少数研究调查了路易体痴呆（DLB）患者的错误记忆。我们初步研究的目的是评估DLB患者的错误记忆，并确定影响DLB和AD患者错误记忆产生的潜在认知缺陷。十名AD患者和九名DLB患者执行了一项记忆任务（自由回忆和识别），该任务结合了两种范式，即促进错误记忆产生的DRM（迪斯-罗迪格-麦克德莫特）范式和用于研究记忆回忆过程中现象学体验的“记住/知道”（R/K）范式。对记忆、执行和工具性能力进行的标准认知评估完善了该评估。在自由回忆过程中，DLB组未发现错误记忆，而在识别过程中两组的错误记忆数量基本相同。然而，错误记忆与现象学体验不同，DLB患者有更多的“知道”（K）反应，AD患者有更多的“记住”（R）反应。标准神经心理学评估的各项测试均与错误记忆的相关测量指标无相关性。在AD患者中，与错误记忆相关的“记住”反应反映了源记忆的改变。在DLB患者中，关键项目会引发熟悉感，但无法回忆起该项目被编码时的情境，因此出现“知道”反应。这表明他们的源记忆得以保留。与预期相反，两组中错误记忆的类型与其认知概况无关。因此，AD和路易体痴呆（LBD）中错误记忆背后的认知过程似乎不同，但错误记忆在这些疾病中似乎独立于记忆和执行能力。
