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二十二碳六烯酸(DHA)对脊髓损伤的影响。

Effect of Docosahexaenoic Acid (DHA) on Spinal Cord Injury.

作者信息

Samaddar Sreyashi

机构信息

Department of Neuroscience/Biology, Research Foundation CUNY, Staten Island, NY, USA.

出版信息

Adv Neurobiol. 2016;12:27-39. doi: 10.1007/978-3-319-28383-8_2.

DOI:10.1007/978-3-319-28383-8_2
PMID:27651246
Abstract

Spinal cord injury (SCI) has become one of the most leading concerns in the past decade. Preclinical and research studies are now ongoing trying to understand the molecular mechanisms and develop treatment strategies for this neurodegenerative condition. In the last decade, researchers have deciphered few of the leading players that play a major role in worsening the condition. But till date none of these have been applied to the clinical treatment of patients with SCI. Here in this chapter I discuss about one of the dietary requirements that could ameliorate the condition of these patients.

摘要

脊髓损伤(SCI)在过去十年中已成为最主要的关注问题之一。目前正在进行临床前和研究性研究,试图了解这种神经退行性疾病的分子机制并制定治疗策略。在过去十年中,研究人员已经破解了一些在病情恶化中起主要作用的关键因素。但迄今为止,这些因素均未应用于脊髓损伤患者的临床治疗。在本章中,我将讨论一种可能改善这些患者病情的饮食需求。

相似文献

1
Effect of Docosahexaenoic Acid (DHA) on Spinal Cord Injury.二十二碳六烯酸(DHA)对脊髓损伤的影响。
Adv Neurobiol. 2016;12:27-39. doi: 10.1007/978-3-319-28383-8_2.
2
Docosahexaenoic acid prevents white matter damage after spinal cord injury.二十二碳六烯酸可预防脊髓损伤后的白质损伤。
J Neurotrauma. 2010 Oct;27(10):1769-80. doi: 10.1089/neu.2010.1348. Epub 2010 Oct 6.
3
In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [(18)F]GE-180 and effect of docosahexaenoic acid.使用TSPO示踪剂[(18)F]GE - 180对大鼠脊髓损伤中神经炎症反应进行的体内PET成像及二十二碳六烯酸的作用。
Eur J Nucl Med Mol Imaging. 2016 Aug;43(9):1710-22. doi: 10.1007/s00259-016-3391-8. Epub 2016 May 7.
4
Alleviating Severe Cytoskeletal Destruction of Spinal Motor Neurons: Another Effect of Docosahexaenoic Acid in Spinal Cord Injury.减轻脊髓运动神经元严重的细胞骨架破坏:二十二碳六烯酸在脊髓损伤中的又一作用。
ACS Chem Neurosci. 2024 Apr 3;15(7):1456-1468. doi: 10.1021/acschemneuro.3c00746. Epub 2024 Mar 12.
5
Do omega-3 polyunsaturated fatty acids ameliorate spinal cord injury?: Commentary on: Lim et al., Improved outcome after spinal cord compression injury in mice treated with docosahexaeonic acid. Exp. Neurol. Jan; 239:13-27.ω-3 多不饱和脂肪酸能否改善脊髓损伤?:述评:Lim 等人,二十二碳六烯酸治疗对小鼠脊髓压迫损伤后结局的改善。Exp. Neurol. 2014 年 1 月;239:13-27。
Exp Neurol. 2013 Nov;249:104-10. doi: 10.1016/j.expneurol.2013.08.008. Epub 2013 Aug 30.
6
Docosahexaenoic acid induces changes in microglia/macrophage polarization after spinal cord injury in rats.二十二碳六烯酸诱导大鼠脊髓损伤后小胶质细胞/巨噬细胞极化的变化。
Acta Histochem. 2018 Nov;120(8):741-747. doi: 10.1016/j.acthis.2018.08.005. Epub 2018 Aug 28.
7
A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury.静脉注射和膳食二十二碳六烯酸相结合可显著改善脊髓损伤后的预后。
Brain. 2007 Nov;130(Pt 11):3004-19. doi: 10.1093/brain/awm223. Epub 2007 Sep 27.
8
Blockade of IL-6 signaling by MR16-1 inhibits reduction of docosahexaenoic acid-containing phosphatidylcholine levels in a mouse model of spinal cord injury.MR16-1对IL-6信号通路的阻断可抑制脊髓损伤小鼠模型中含二十二碳六烯酸的磷脂酰胆碱水平的降低。
Neuroscience. 2014 Jun 6;269:1-10. doi: 10.1016/j.neuroscience.2014.03.012. Epub 2014 Mar 20.
9
Omega-3 fatty acids and neurological injury.Omega-3脂肪酸与神经损伤
Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec;77(5-6):295-300. doi: 10.1016/j.plefa.2007.10.021. Epub 2007 Nov 26.
10
Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning.饮食和/或运动对增强脊髓感觉运动学习的影响。
PLoS One. 2012;7(7):e41288. doi: 10.1371/journal.pone.0041288. Epub 2012 Jul 20.

引用本文的文献

1
Co-Delivery of Docosahexaenoic Acid and Brain-Derived Neurotropic Factor from Electrospun Aligned Core-Shell Fibrous Membranes in Treatment of Spinal Cord Injury.从电纺排列核壳纤维膜中共同递送二十二碳六烯酸和脑源性神经营养因子用于治疗脊髓损伤
Pharmaceutics. 2022 Jan 28;14(2):321. doi: 10.3390/pharmaceutics14020321.
2
The effect of dietary supplementation with high- or low-dose omega-3 fatty acid on inflammatory pathology after traumatic brain injury in rats.高剂量或低剂量ω-3脂肪酸膳食补充对大鼠创伤性脑损伤后炎症病理的影响。
Transl Neurosci. 2021 Feb 4;12(1):76-82. doi: 10.1515/tnsci-2021-0010. eCollection 2021 Jan 1.
3
Innovative mouse model mimicking human-like features of spinal cord injury: efficacy of Docosahexaenoic acid on acute and chronic phases.
创新性模拟人类脊髓损伤特征的小鼠模型:二十二碳六烯酸对急慢性期的疗效。
Sci Rep. 2019 Jun 20;9(1):8883. doi: 10.1038/s41598-019-45037-x.
4
Resolvin D1 Halts Remote Neuroinflammation and Improves Functional Recovery after Focal Brain Damage Via ALX/FPR2 Receptor-Regulated MicroRNAs.解析 D1 通过 ALX/FPR2 受体调节的 microRNAs 阻断远程神经炎症并改善局灶性脑损伤后的功能恢复。
Mol Neurobiol. 2018 Aug;55(8):6894-6905. doi: 10.1007/s12035-018-0889-z. Epub 2018 Jan 22.