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50克口服葡萄糖耐量试验:它是妊娠期糖尿病的有效筛查试验吗?

50 Grams Oral Glucose Challenge Test: Is It an Effective Screening Test for Gestational Diabetes Mellitus?

作者信息

Abu-Heija Adel, Al-Bash Majeda, Ishrat Noreen, Al-Kharausi Lamya

机构信息

Department of Obstetrics and Gynecology, Sultan Qaboos University and Hospital, Muscat, Oman.

出版信息

J Obstet Gynaecol India. 2016 Oct;66(Suppl 1):7-11. doi: 10.1007/s13224-015-0752-3. Epub 2015 Aug 29.

Abstract

AIM

To find out whether 50 g oral glucose challenge test (OGCT) is an effective screening test for all pregnant women between 24 and 28 weeks gestation.

METHOD

A 50 g OGCT test was administered to 307 unselected women at 24-28 weeks of gestation. When venous plasma glucose (VPG) concentration after 1 h was >7.8 mmol/l, OGCT was positive. Women with a positive OGCT underwent 2 h 75 grams oral glucose tolerance test (OGTT) as a confirmatory diagnosis of GDM. When fasting and 2 h post 75 g OGTT values were >5.5 mmol/I and >8 mmol/l, respectively, women were considered diabetic.

RESULTS

We screened 307 women for GDM by OGCT. Total number of women with positive OGCT was 83 (27.03 %). In the low-risk group, total number of women with GDM was 9/168 (5.35 %) while the total number of women with GDM in the high-risk group was 14/139 (10.07 %). There was no significant difference with respect to the total number of women with GDM in the groups.

CONCLUSIONS

A 50 g OGCT seems to be an effective screening test for both groups. More cases of GDM can be discovered when universal rather than risk-related screening is applied.

摘要

目的

探讨50克口服葡萄糖耐量试验(OGCT)是否为孕24至28周所有孕妇的有效筛查试验。

方法

对307例孕24 - 28周未经过筛选的孕妇进行50克OGCT试验。1小时后静脉血浆葡萄糖(VPG)浓度>7.8 mmol/L时,OGCT为阳性。OGCT阳性的孕妇接受2小时75克口服葡萄糖耐量试验(OGTT)以确诊妊娠期糖尿病(GDM)。当空腹及75克OGTT后2小时的值分别>5.5 mmol/L和>8 mmol/L时,该孕妇被视为糖尿病患者。

结果

我们通过OGCT对307例孕妇进行GDM筛查。OGCT阳性的孕妇总数为83例(27.03%)。在低风险组中,GDM孕妇总数为9/168(5.35%),而高风险组中GDM孕妇总数为14/139(10.07%)。两组中GDM孕妇总数无显著差异。

结论

50克OGCT似乎对两组都是有效的筛查试验。采用普遍筛查而非与风险相关的筛查时,可以发现更多GDM病例。

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