多囊卵巢综合征患者腹腔镜卵巢电灼术后的激素变化
Hormonal Changes After Laparoscopic Ovarian Diathermy in Patients with Polycystic Ovarian Syndrome.
作者信息
Elnaggar Elsayed A, Elwan Youssef Abo, Ibrahim Safaa A, Abdalla Mena M
机构信息
Department of Obstetrics and Gynecology, Zagazig University Hospital, Zagazig, Egypt.
Department of Obstetrics and Gynecology, Menia Health Insurance Hospital, El Ménia, Egypt.
出版信息
J Obstet Gynaecol India. 2016 Oct;66(Suppl 1):528-33. doi: 10.1007/s13224-016-0882-2. Epub 2016 Apr 13.
AIM OF THE PRESENT STUDY
To assess the changes in hormonal profile (serum FSH, LH, prolactin and total testosterone) following laparoscopic ovarian drilling (LOD) in patients with polycystic ovarian syndrome.
MATERIALS AND METHODS
Fifty patients with PCOS have been included in this study. Serum prolactin, total testosterone, follicular-stimulating hormone (FSH) and luteinizing hormone (LH) levels have been used as biochemical markers, before and after procedures.
RESULTS
Laparoscopic ovarian drilling was successfully employed without any surgical complications and on an average follow-up time of 24 weeks after the procedure. During the follow-up serum values for prolactin, total testosterone and LH have decreased significantly and FSH levels remained unchanged after the procedure.
CONCLUSIONS
The LOD in patients with PCOS may avoid or reduce the risk of OHSS and the multiple pregnancy rate induced by gonadotropin therapy. The high pregnancy rate and the economic aspect of the procedure offer an attractive management for patients with PCOS. However, LOD can be considered as second-line treatment after clomiphene citrate treatment failure and/or resistance.
本研究目的
评估多囊卵巢综合征患者行腹腔镜卵巢打孔术（LOD）后激素水平（血清促卵泡生成素、促黄体生成素、催乳素和总睾酮）的变化。
材料与方法
本研究纳入了50例多囊卵巢综合征患者。术前及术后均采用血清催乳素、总睾酮、促卵泡刺激素（FSH）和促黄体生成素（LH）水平作为生化指标。
结果
成功实施腹腔镜卵巢打孔术，无任何手术并发症发生，术后平均随访24周。随访期间，催乳素、总睾酮和LH的血清值显著下降，术后FSH水平保持不变。
结论
多囊卵巢综合征患者行腹腔镜卵巢打孔术可避免或降低卵巢过度刺激综合征（OHSS）风险以及促性腺激素治疗引起的多胎妊娠率。该手术的高妊娠率及经济优势为多囊卵巢综合征患者提供了有吸引力的治疗方案。然而，腹腔镜卵巢打孔术可在枸橼酸氯米芬治疗失败和/或耐药后作为二线治疗方法。
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